急性缺血性脑卒中阿替普酶静脉溶栓相关并发症的临床研究进展

被引:33
作者
石宝洋
靳航
杨弋
机构
[1] 吉林大学白求恩第一医院神经内科
关键词
静脉溶栓; ICH; 独立危险因素; 急性缺血性脑卒中; 阿替普酶; 相关并发症;
D O I
10.19845/j.cnki.zfysjjbzz.2018.03.023
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
<正>脑卒中已跃升至人类的第二大死亡原因,其高发病率、高致残率、高死亡率以及高复发率给家庭、社会及国家带来了沉重的负担。70%~80%的脑卒中为缺血性脑卒中。"时间就是大脑"的治疗观念已得到大多数学者的认可,因此早期治疗、尽早开通梗死相关血管是缺血性脑卒中超急性期的最重要治疗原则,阿替普酶静脉溶栓治疗是临床上治疗急性缺血性脑卒中的里程碑,它为早期开通梗死相关血管提供了可能,在其被批准用于急性缺血性脑卒中临床治疗20余年里,在急性缺血性脑卒中治疗中发挥了不可替代的作用。被
引用
收藏
页码:275 / 278
页数:4
相关论文
共 24 条
[1]  
Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin‐converting enzyme inhibitor use[J] . S.‐Y. Lin,S.‐C. Tang,L.‐K. Tsai,S.‐J. Yeh,Y.‐J. Hsiao,Y.‐W. Chen,K.‐H. Chen,B.‐S. Yip,L.‐J. Shen,F.‐L. Lin Wu,J.‐S. Jeng.Eur J Neurol . 2014 (10)
[2]   Blood Pressure Management and Evolution of Thrombolysis-associated Intracerebral Hemorrhage in Acute Ischemic Stroke [J].
Mokin, Maxim ;
Kass-Hout, Tareq ;
Kass-Hout, Omar ;
Zivadinov, Robert ;
Mehta, Bijal .
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2012, 21 (08) :852-859
[3]  
Risk Factors for Intracranial Hemorrhage in Acute Ischemic Stroke Patients Treated With Recombinant Tissue Plasminogen Activator: A Systematic Review and Meta-Analysis of 55 Studies[J] . William N. Whiteley,Karsten Bruins Slot,Peter Fernandes,Peter Sandercock,Joanna Wardlaw.Stroke . 2012 (11)
[4]  
Lingual angioedema with macroglossia during the treatment of acute ischemic stroke with alteplase[J] . Josef Yayan.International Journal of General Medicine . 2012 (defa)
[5]  
Timeliness of Tissue-Type Plasminogen Activator Therapy in Acute Ischemic Stroke: Patient Characteristics, Hospital Factors, and Outcomes Associated With Door-to-Needle Times Within 60 Minutes[J] . Gregg C. Fonarow,Eric E. Smith,Jeffrey L. Saver,Mathew J. Reeves,Deepak L. Bhatt,Maria V. Grau-Sepulveda,DaiWai M. Olson,Adrian F. Hernandez,Eric D. Peterson,Lee H. Schwamm.Circulation . 2011 (7)
[6]  
Implementation and outcome of thrombolysis with alteplase 3–4·5 h after an acute stroke: an updated analysis from SITS-ISTR[J] . Niaz Ahmed,Nils Wahlgren,Martin Grond,Michael Hennerici,Kennedy R Lees,Robert Mikulik,Mark Parsons,Risto O Roine,Danilo Toni,Peter Ringleb.Lancet Neurology . 2010 (9)
[7]  
Orolinguales Angio?dem unter systemischer Thrombolyse mit rt-PA[J] . C. Ottomeyer,C. Sick,M.G. Hennerici,K. Szabo.Der Nervenarzt . 2009 (4)
[8]  
Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial[J] . Stephen M Davis,Geoffrey A Donnan,Mark W Parsons,Christopher Levi,Kenneth S Butcher,Andre Peeters,P Alan Barber,Christopher Bladin,Deidre A De Silva,Graham Byrnes,Jonathan B Chalk,John N Fink,Thomas E Kimber,David Schultz,Peter J Hand,Judith Frayne,Graeme Hankey,Keith Muir,Richard Gerraty,Brian M Tress,Patricia M Desmond.Lancet Neurology . 200
[9]  
Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke[J] . W. Hacke,M. Kaste,E. Bluhmki.Journal of Vascular Surgery . 2008 (6)
[10]  
Reperfusion Seizures: A Manifestation of Cerebral Reperfusion Injury After Administration of Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke[J] . Faizan Hafeez,Mohammad A. Razzaq,Ross L. Levine,Mark Allan N. Ramirez.Journal of Stroke and Cerebrovascular Diseases . 2007 (6)