NF-kB的研究进展

被引：19

作者：

金晶

刘耕陶

机构：

[1] 中国医学科学院,中国协和医科大学药物研究所!北京

来源：

国外医学药学分册. | 2000年 / 03期

关键词：

NF-κB; NF-κB抑制蛋白; 凋亡; 癌症; 神经退行性疾病;

D O I：

10.13220/j.cnki.jipr.2000.03.002

中图分类号：

R915 [药物生物学];

学科分类号：

1007 ;

摘要：

核因子 κB(NF- κB)是能调节多种炎症和免疫基因表达的一种重要的转录调节因子 ,它在胞浆内与 NF- κB抑制蛋白 (IκB)结合呈非活性状态 ,一旦被病毒、氧化剂、炎症细胞因子等刺激剂激活后便与 IκB解离而转入核内与特异的启动子结合 ,从而调控基因的表达。 NF-κB过度激活与许多病理现象有关 ,例如类风湿性关节炎、哮喘、艾滋病、动脉粥样硬化、神经退行性疾病等 ,而 NF-κB被抑制则与癌症、免疫细胞发育不全、细胞生长延迟等有关。因此 ,针对 NF-κB活性的激活与抑制 ,从不同环节去寻找药物用于治疗和预防与 NF- κB有关的疾病 ,是当前药物研究的一个新靶点

引用

页码：133 / 137

页数：5

共 16 条

[1]

Packer L redox regulation of NF-kappa B activation. Flohe L,Brigelius-Flohe R,Saliou C,et al. Free Radical Biology and Medicine . 1997

[2]

Control of inducible chemoresistance: enhanced anti -tumor therapy through increased apoptosis by inhibition of NFkappa B. Wang CY,Cusack JC Jr,Liu R,et al. Nature Medicine . 1999

[3]

Immunosuppression by glucocorticoids: inhibition of NF- B activity through induction of I B synthesis. Auphan N,DiDonato JA,Rosette C,et al. Science . 1995

[4]

Insulin-like growth factor -1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kappa B. Heck S,Lezoualc′h F,Engert S,et al. Journal of Biological Chemistry . 1999

[5]

Rel NF- B I B proteins and cancer. Gilmore TD,Koedood M,Piffat KA,et al. Oncegene . 1996

[6]

NF-kappa B function in growth control : regulation of cyclin D1 expression and G0 G1-to-S-phase transition. Hinz M,Krappmann D,Eichten A. Molecular and Cellular Biology . 1999

[7]

NF- B immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer ′s disease. Ferrer I,Marti E,Lopez E,et al. Neuropathology and Applied Neurobiology . 1998

[8]

NF- B: a crucial transcription factor for glial and neuronal cell function. O′Neill LA,Kaltschmidt C. Trends in Neurosciences . 1997

[9]

NF- B activation: the I B kinase revealed. Stancovaski I,Baltimore D. Cell . 1997

[10]

Multiple redox regulation in NF- B transcription factor activation. Piette J,Piret B. Biological Chemistry . 1997

← 1 2 →