定量CT评价老年2型糖尿病患者腰椎骨密度及骨折的研究

被引：11

作者：

潘艳丽 ^{[1
]}

唐松涛 ^{[1
]}

窦家庆 ^{[2
]}

何勇 ^{[1
]}

代芳 ^{[1
]}

杨洋 ^{[3
]}

赵广碧 ^{[4
]}

任邦树 ^{[5
]}

章秋 ^{[1
]}

机构：

[1] 安徽医科大学第一附属医院内分泌科

[2] 巢湖市第一人民医院内分泌科

[3] 安徽医科大学第一附属医院骨密度室

[4] 安徽医科大学第一附属医院内分泌实验室

[5] 安徽医科大学第一附属医院影像科

来源：

中国骨质疏松杂志 | 2012年 / 18卷 / 04期

关键词：

2型糖尿病; 骨密度; 定量CT; 双能X线骨密度;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

100201 [内科学];

摘要：

目的明确老年2型糖尿病(T2DM)患者腰椎骨密度及骨折发生率之间的关系。方法每年随访97例老年T2DM患者的糖化血红蛋白,记录骨折等不良事件。于第0、3、7年用DEXA测定腰椎BMD,第7年测定患者及同龄正常对照组(20例)腰椎的DEXA骨密度(aBMD)及QCT骨密度(vBMD)。结果老年(T2DM)患者腰椎aBMD随年龄增长逐渐下降,差异有显著性(P>0.05),第7年时与第3年时比较仍下降但差异无显著性(P>0.05)。有13名患者发生非暴力性骨折,糖尿病骨折组、非骨折组及对照组相比,腰椎aBMD均未见显著差异(P>0.05);糖尿病骨折组vBMD最低,与非骨折组及对照组比较差异有显著性(P<0.05);多重回归分析腰椎aBMD与糖化血红蛋白相关性差异无显著性(P>0.05)。结论①老年2型糖尿病患者腰椎aBMD随年龄增长逐渐下降,但与正常同龄人无显著差异;②腰椎aBMD与糖化血红蛋白无显著相关性;②老年T2DM合并骨折病史者腰椎vBMD显著下降但aBMD无显著改变,提示对老年2型糖尿病患者QCT对预测骨折可能具有良好临床应用前景。

引用

收藏

页码：323 / 326+304 +304

页数：5

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