血清脂质、脂质过氧化与动脉粥样硬化

被引:12
作者
郭虹
陈在嘉
徐义枢
机构
[1] 中国医学科学院心血管病研究所、阜外医院,中国医学科学院心血管病研究所、阜外医院,中国医学科学院心血管病研究所、阜外医院
关键词
脂质过氧化; AS; 血清; LPO; LDL; 动脉粥样硬化; 动脉硬化;
D O I
暂无
中图分类号
学科分类号
摘要
<正> 高脂血症是动脉粥样硬化(AS)性疾病易患因素之一,其机制尚在研究中。1952年,Glavind等首先发现在AS斑块中有大量脂质过氧化物(LPO),后又发现AS疾病患者血浆LPO升高,认为AS发生可能与脂质过氧化性损伤有关。
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页码:86 / 88
页数:3
相关论文
共 13 条
[1]  
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. Heinecke JW,Baker L,Rosen H,et al. The Journal of Clinical Investigation . 1986
[2]  
Helsinki Heart Study, Primary-prevention trial with gemfibrozil in middle aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease. Frick MH,Elo O,Haaps K,et al. The New England Journal of Medicine . 1987
[3]  
Superoxide anion is an endothelium-derived contracting factor. Katusic ZS,Vanhoutte PM. American Journal of Physiology . 1989
[4]  
Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24
[5]  
Lipid peroxidation of endothelial cells induced by oxygen-radicals derived from ??loukocytes. Nishida M,Kuzuya T,Hoshida S,et al. Circulation . 1989
[6]  
Diabetes[P]. 英国专利:GB201117172D0,2011-11-16
[7]  
Evidence for the presenco of oxidatively modified low density lipoproteins in atherosclerosis lesions of rabbit and man. Yla-Herttuala S,Palsinki W,Rosenfeld ME,et al. The Journal of Clinical Investigation . 1989
[8]  
The presence of peroxidized lipid, in the atherosclerotic aorta. Glavind J,Hartmann S,Clemmens J,et al. Acta Pathologica Microbiologica et Immunologica Scandinavica . 1952
[9]  
The metabolism of native and malondialdehyde-alterd low density lipoproteins by human monocyte macrophages. Shechter I,Fogelman AM,Haberland ME,et al. Journal of Lipid Research . 1981
[10]  
Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24