非布司他对痛风合并高尿酸血症患者血清sICAM-1,ET-1及尿酸水平的影响

被引：27

作者：

张文

解为慈

徐金娥

刘文

张先君

机构：

[1] 湖北科技学院附属天门医院内分泌科

来源：

现代生物医学进展 | 2016年 / 16卷 / 27期

关键词：

非布司他; 痛风; 高尿酸血症; 内皮素-1; 细胞间粘附分子-1; 尿酸;

D O I：

10.13241/j.cnki.pmb.2016.27.027

中图分类号：

R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

100201 [内科学];

摘要：

目的:探讨非布司他对痛风合并高尿酸血症患者血清内皮素-1(ET-1)、细胞间粘附分子-1(ICAM-1)及尿酸水平的影响。方法:收集在我院就诊或住院治疗的80例痛风合并高尿酸血症患者,随机分为实验组和对照组,每组40例。对照组患者给予别嘌呤醇片治疗;实验组患者给予非布司他片治疗。观察并比较两组患者治疗前后血尿酸、s ICAM-1、ET-1水平及临床疗效。结果:与治疗前相比,两组患者治疗后的血尿酸、s ICAM-1、ET-1水平均显著降低(P<0.05);与对照组相比,实验组患者的血尿酸、s ICAM-1、ET-1水平较低(P<0.05),临床治疗总有效率较高(P<0.05)。结论:非布司他能够降低痛风合并高尿酸血症的s ICAM-1、ET-1及尿酸水平,且临床疗效较好。

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收藏

页码：5303 / 5305

页数：3

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