药物所致肝纤维化动物模型的研究进展

被引：15

作者：

刘立新

石永强

机构：

[1] 山西医科大学第一医院科研实验中心

来源：

中国药物与临床 | 2009年 / 9卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R575.2 [肝硬变]; R595.3 [药源性疾病];

学科分类号：

100201 [内科学];

摘要：

<正>肝纤维化是细胞外基质在肝内过度沉积的病变,是发展为肝硬化的重要中间环节。目前认为,肝纤维化是可逆的,但若没有得到及时有效的治疗,则最终发展为不可逆转的肝硬化、甚至肝癌。因此,如何有效地防治肝纤维化,阻断其进展,已经成为国内外研究的热点。为了研究肝纤维化的发生机制并筛选出有效的治疗药物,需要建立良好的肝纤维化动物模型。

引用

页码：851 / 853

页数：3

共 12 条

[1]

Analysis of hepatic gene expression during fatty liver change due to chronic ethanol administration in mice [J].

Yin, Hu-Quan ;

Je, Young-Tae ;

Kim, Mingoo ;

Kim, Ju-Han ;

Kong, Gu ;

Kang, Kyung-Sun ;

Kim, Hyung-Lae ;

Yoon, Byung-Il ;

Lee, Mi-Ock ;

Lee, Byung-Hoon .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 235 (03) :312-320

[2]

Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells [J].

Liu, Hao ;

Wei, Wei ;

Sun, Wu-yi ;

Li, Xiang .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 122 (03) :502-508

[3]

The development and progression of cholangiocarcinoma induced by chronic administration of thioacetamide (TAA) are enhanced by leptin.[J].G. Fava;C. Rychlicki;S. Saccomanno;L. Trozzi;C. Candelaresi;A. Di Sario;M. Marzioni;G. Alpini;A. Benedetti.Digestive and Liver Disease.2008, 10

[4]

269 THIOACETAMIDE-INDUCED FULMINANT HEPATIC ENCEPHALOPATHY ON ADULT RAT BRAIN PARAMETERS: CORRELATION WITH THE EFFECTS PRODUCED BY IN VITRO TREATMENT WITH AMMONIA.[J].A. Zarros;S. Theocharis;N. Skandali;S. Tsakiris.Journal of Hepatology.2008,

[5]

Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation [J].