吸入地塞米松对哮喘豚鼠内皮素-1的影响

被引:2
作者
钱效森
林耀广
孙梅励
朱元珏
罗慰慈
机构
[1] 中国医学科学院中国协和医科大学北京协和医院呼吸科!北京
[2] 中国医学科学院
关键词
支气管哮喘; 内皮素; 支气管肺泡灌洗液;
D O I
暂无
中图分类号
R562.25 [];
学科分类号
1002 ; 100201 ;
摘要
建立豚鼠哮喘模型,检测肺活组织、支气管肺泡灌洗液(SALF)、血浆内皮素-1(ET-1)水平及地塞米松干预后的变化以探讨ET-1在支气皆哮喘发病中的作用。结果显示哮喘组肺活组织、BALF、血浆ET-1显著升高;吸入地塞米松后ET-1均显著下降。提示:ET-1可能参与支气管哮喘的发生和发展,吸入糖皮质激素可以抑制体内ET-1的生成和释放,这可能是糖皮质激素治疗支气管哮喘的重要机制之一。
引用
收藏
页码:58 / 60
页数:3
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