药动学-药效学结合模型的研究进展

被引:8
作者
赵刚
田长青
李静
机构
[1] 山东省医学科学院药物研究所
关键词
药动学; 药效学; 药动学药效学模型; 临床试验;
D O I
暂无
中图分类号
R969.1 [药物代谢动力学];
学科分类号
摘要
本文主要对近年来药动学药效学结合模型在模型建立、药理学、毒理学、临床应用及新药研发等方面的进展进行了综述,并展望其发展前景。
引用
收藏
页码:361 / 366
页数:6
相关论文
共 3 条
[1]  
Modeling of Pharmacokinetic/Pharmacodynamic (PK/PD) Relationships: Concepts and Perspectives[J] . Hartmut Derendorf,Bernd Meibohm.Pharmaceutical Research . 1999 (2)
[2]   Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver [J].
Sun, YN ;
DuBois, DC ;
Almon, RR ;
Pyszczynski, NA ;
Jusko, WJ .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1998, 26 (06) :619-648
[3]   PHARMACOKINETIC DYNAMIC CORRELATION OF PULMONARY AND CARDIAC EFFECTS OF FENOTEROL IN ASTHMATIC-PATIENTS AFTER DIFFERENT ROUTES OF ADMINISTRATION [J].
HOCHHAUS, G ;
SCHMIDT, EW ;
ROMINGER, KL ;
MOLLMANN, H .
PHARMACEUTICAL RESEARCH, 1992, 9 (03) :291-297