表观遗传学在胃癌中的应用价值

被引：7

作者：

李亚卓 ^{[1
]}

郭明洲 ^{[2
]}

赵坡 ^{[1
]}

机构：

[1] 中国人民解放军总医院病理科

[2] 中国人民解放军总医院消化科

来源：

胃肠病学和肝病学杂志 | 2011年 / 20卷 / 07期

关键词：

表观遗传学; 胃癌; DNA甲基化; 组蛋白修饰; 非编码RNA;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

表观遗传学是一门研究基因表达的学科,其主要研究内容包括DNA甲基化、组蛋白修饰和非编码RNA。在胃癌的发生过程中表观遗传学的作用越来越受到人们的重视,特别是DNA甲基化改变的临床价值已被广泛接受。表观遗传学的变化不仅可用于胃癌的早期诊断,而且还可用作预后和化疗敏感性的指标。本文将对表观遗传学在胃癌中的应用价值进行较为系统的评价。

引用

收藏

页码：589 / 593

页数：5

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