脓毒症的诊断及治疗进展

被引:17
作者
严静
沈延飞
机构
[1] 浙江医院重症医学科
关键词
脓毒症; 脓毒症休克; 抗感染; 液体复苏;
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
脓毒症是重症患者的常见综合征,具有极高的致死率和致残率。目前对于脓毒症的早期诊断仍缺乏有效的手段,新型生物标志物以及基因组学的发展可能带来新的突破。脓毒症治疗方面目前也较困难,其中感染源的早期鉴别以及有效的液体复苏是脓毒症治疗的根本。质谱图数据库以及宏基因测序等可为临床医生提供有用的建议。而个体化的液体复苏策略则更应贯穿整个脓毒症诊治过程。本文拟从脓毒症诊断的拟定、生物标志物的现况以及脓毒症主要诊疗策略衍变等方面作一述评。
引用
收藏
页码:1479 / 1482+1488 +1488
页数:5
相关论文
共 15 条
[1]
A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study [J].
Engoren, Milo ;
Seelhammer, Troy ;
Freundlich, Robert E. ;
Maile, Michael D. ;
Sigakis, Matthew J. G. ;
Schwann, Thomas A. .
CRITICAL CARE MEDICINE, 2020, 48 (09) :1258-1264
[2]
Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment [J].
Prasad, Priya A. ;
Fang, Margaret C. ;
Abe-Jones, Yumiko ;
Calfee, Carolyn S. ;
Matthay, Michael A. ;
Kangelaris, Kirsten N. .
CRITICAL CARE MEDICINE, 2020, 48 (02) :200-209
[3]
Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial [J].
Liu, Zi-Meng ;
Chen, Juan ;
Kou, Qiuye ;
Lin, Qinhan ;
Huang, Xiaobo ;
Tang, Zhanhong ;
Kang, Yan ;
Li, Ke ;
Zhou, Lixin ;
Song, Qing ;
Sun, Tongwen ;
Zhao, Ling ;
Wang, Xue ;
He, Xiandi ;
Wang, Chunting ;
Wu, Benquan ;
Lin, Jiandong ;
Yuan, Shiying ;
Gu, Qin ;
Qian, Kejian ;
Shi, Xianqing ;
Feng, Yongwen ;
Lin, Aihua ;
He, Xiaoshun ;
Guan, Xiang-Dong .
INTENSIVE CARE MEDICINE, 2018, 44 (11) :1816-1825
[4]
Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock [J].
Stenson, Erin K. ;
Cvijanovich, Natalie Z. ;
Allen, Geoffrey L. ;
Thomas, Neal J. ;
Bigham, Michael T. ;
Weiss, Scott L. ;
Fitzgerald, Julie C. ;
Jain, Parag N. ;
Meyer, Keith ;
Quasney, Michael ;
Hall, Mark ;
Gedeit, Rainer ;
Freishtat, Robert J. ;
Nowak, Jeffrey ;
Lutfi, Riad ;
Gertz, Shira ;
Grunwell, Jocelyn R. ;
Wong, Hector R. ;
Anas, Nick .
INTENSIVE CARE MEDICINE, 2018, 44 (11) :2004-2005
[5]
Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy.[J].Manu L. N. G. Malbrain;Niels Van Regenmortel;Bernd Saugel;Brecht De Tavernier;Pieter-Jan Van Gaal;Olivier Joannes-Boyau;Jean-Louis Teboul;Todd W. Rice;Monty Mythen;Xavier Monnet.Annals of Intensive Care.2018, 1
[6]
Effect of hyperchloremia on acute kidney injury in critically ill septic patients: a retrospective cohort study [J].
Yessayan, Lenar ;
Neyra, Javier A. ;
Canepa-Escaro, Fabrizio ;
Vasquez-Rios, George ;
Heung, Michael ;
Yee, Jerry .
BMC NEPHROLOGY, 2017, 18
[7]
Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit [J].
Raith, Eamon P. ;
Udy, Andrew A. ;
Bailey, Michael ;
McGloughlin, Steven ;
MacIsaac, Christopher ;
Bellomo, Rinaldo ;
Pilcher, David V. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 317 (03) :290-300
[8]
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).[J].Christopher W. Seymour;Vincent X. Liu;Theodore J. Iwashyna;Frank M. Brunkhorst;Thomas D. Rea;André Scherag;Gordon Rubenfeld;Jeremy M. Kahn;Manu Shankar-Hari;Mervyn Singer;Clifford S. Deutschman;Gabriel J. Escobar;Derek C. Angus.JAMA.2016, 8
[9]
Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis [J].
Kaukonen, Kirsi-Maija ;
Bailey, Michael ;
Pilcher, David ;
Cooper, D. Jamie ;
Bellomo, Rinaldo .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (17) :1629-1638
[10]
Diagnostic and prognostic utility of soluble CD 14 subtype (presepsin) for severe sepsis and septic shock during the first week of intensive care treatment [J].
Behnes, Michael ;
Bertsch, Thomas ;
Lepiorz, Dominic ;
Lang, Siegfried ;
Trinkmann, Frederik ;
Brueckmann, Martina ;
Borggrefe, Martin ;
Hoffmann, Ursula .
CRITICAL CARE, 2014, 18 (05)