胆碱酯酶抑制剂在痴呆治疗中的应用现状

被引:4
作者
魏翠柏
周爱红
王芬
贾建平
机构
[1] 首都医科大学宣武医院神经内科
关键词
阿尔茨海默病; 胆碱酯酶抑制剂; 痴呆; 疗效;
D O I
暂无
中图分类号
R749.1 [脑器质性精神障碍];
学科分类号
摘要
<正>20世纪初痴呆的概念被最终确定在认知功能的范畴,即痴呆是由多种原因引起的一种以认知功能障碍为主要表现的后天获得性临床综合征。在过去几十年中,痴呆的治疗一直是研究者关注的焦点。在循证医学引导下,第2代胆碱酯酶抑制剂多奈哌齐、卡巴拉汀、加兰他敏的适应证,已由最初治疗轻中度
引用
收藏
页码:948 / 949
页数:2
相关论文
共 12 条
[1]  
Cholinesterase inhibitor use is associated with increased plasma levels of anti-Abeta 1–42 antibodies in Alzheimer’s disease patients[J] . Elisa Conti,Gloria Galimberti,Lucio Tremolizzo,Alessandro Masetto,Diletta Cereda,Clara Zanchi,Fabrizio Piazza,Marco Casati,Valeria Isella,Ildebrando Appollonio,Carlo Ferrarese.Neuroscience Letters . 2010 (3)
[2]  
Safety and efficacy of galantamine (Reminyl) in severe Alzheimer’s disease (the SERAD study): a randomised, placebo-controlled, double-blind trial[J] . Lancet Neurology . 2009 (1)
[3]  
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL[J] . Martin Dichgans,Hugh S Markus,Stephen Salloway,Auli Verkkoniemi,Margaret Moline,Qin Wang,Holly Posner,Hugues S Chabriat.Lancet Neurology . 2008 (4)
[4]  
Galantamine treatment of vascular dementia: A randomized trial[J] . A P. Auchus,H R. Brashear,S Salloway,A D. Korczyn,P P. De Deyn,C Gassmann-Mayer.Neurology . 2007 (5)
[5]  
Preliminary Findings: Behavioral Worsening on Donepezil in Patients With Frontotemporal Dementia[J] . Mario F. Mendez,Jill S. Shapira,Aaron McMurtray,Eliot Licht.American Journal of Geriatric Psychiatry . 2007 (1)
[6]  
Treatment of vascular dementia—evidence from clinical trials with cholinesterase inhibitors[J] . Timo Erkinjuntti,Gustavo Román,Serge Gauthier.Journal of the Neurological Sciences . 2004 (1)
[7]  
Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial[J] . Courtney C,Farrell D,Gray R,Hills R,Lynch L,Sellwood E,Edwards S,Hardyman W,Raftery J,Crome P,Lendon C,Shaw H,Bentham P.The Lancet . 2004 (9427)
[8]  
Efficacy of galantamine in probable vascular dementia and Alzheimer’s disease combined with cerebrovascular disease: a randomised trial[J] . Timo Erkinjuntti,Alexander Kurz,Serge Gauthier,Roger Bullock,Sean Lilienfeld,ChandrasekharRao Venkata Damaraju.The Lancet . 2002 (9314)
[9]   The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia [J].
Werber, EA ;
Rabey, JM .
JOURNAL OF NEURAL TRANSMISSION, 2001, 108 (11) :1319-1325
[10]  
Efficacy and Safety of Rivastigmine in Patients with Alzheimer’s Disease: International Randomised Controlled Trial[J] . Michael R?sler,Ravi Anand,Ana Cicin-Sain,Serge Gauthier,Yves Agid,Peter Dal-Bianco,Hannes B. St?helin,Richard Hartman,Marguirguis Gharabawi.BMJ: British Medical Journal . 1999 (7184)