细菌鞭毛蛋白作为佐剂的研究进展

被引:3
作者
宋丽
郭亚鑫
徐慧
熊丹
潘志明
焦新安
机构
[1] 扬州大学江苏省人兽共患病学重点实验室,江苏省动物重要疫病与人兽共患病防控协同创新中心
关键词
鞭毛蛋白; 佐剂; Toll样受体5; NOD样受体C4; 疫苗;
D O I
10.16437/j.cnki.1007-5038.2015.04.021
中图分类号
S852.4 [家畜免疫学];
学科分类号
090602 ;
摘要
细菌鞭毛蛋白作为Toll样受体5(TLR5)或NOD样受体C4(NLRC4)的配体,其结构决定了其既有抗原性又具有佐剂效应。将细菌鞭毛蛋白与外源抗原混合或融合表达,已获得多种有效的候选疫苗。细菌鞭毛蛋白佐剂效应主要是通过TLR5和NLRC4信号途径协同实现的。TLR5位于细胞表面,可触发炎性因子、趋化因子和Ⅰ型干扰素的分泌,启动天然免疫应答。NLRC4是细胞质中的模式识别受体,可识别细胞质中的多种配体并诱导相应免疫应答。另外,细菌鞭毛蛋白能募集T淋巴细胞和B淋巴细胞至次级淋巴器官,促进DCs和T淋巴细胞的活化。细菌鞭毛蛋白的可塑性将会使得以细菌鞭毛蛋白为基础的疫苗成为当前和未来研究的热点。
引用
收藏
页码:92 / 95
页数:4
相关论文
共 11 条
  • [1] Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin
    Diana Kozlova
    Viktoriya Sokolova
    Maohua Zhong
    Ejuan Zhang
    Jingyi Yang
    Wei Li
    Yi Yang
    Jan Buer
    Astrid Maria Westendorf
    Matthias Epple
    Huimin Yan
    [J]. Virologica Sinica, 2014, 29 (01) : 33 - 39
  • [2] 鼠伤寒沙门菌鞭毛蛋白与新城疫病毒F蛋白的融合表达及免疫原性分析
    游猛
    潘志明
    耿士忠
    马全刚
    方强
    焦新安
    [J]. 动物医学进展, 2010, 31 (02) : 20 - 25
  • [3] Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses
    Lage, Silvia L.
    Buzzo, Carina L.
    Amaral, Eduardo P.
    Matteucci, Kely C.
    Massis, Liliana M.
    Icimoto, Marcelo Y.
    Carmona, Adriana Karaoglanovic
    D'Imperio Lima, Maria R.
    Rodrigues, Mauricio M.
    Ferreira, Luis C. S.
    Amarante-Mendes, Gustavo P.
    Bortoluci, Karina R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (35) : E3321 - E3330
  • [4] TLR5 functions as an endocytic receptor to enhance flagellin‐specific adaptive immunity[J] . Shirdi E.Letran,Seung‐JooLee,Shaikh M.Atif,SatoshiUematsu,ShizuoAkira,Stephen J.McSorley.Eur. J. Immunol. . 2010 (1)
  • [5] Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy
    Liu, Fang
    Yang, Jingyi
    Zhang, Yan
    Zhou, Dihan
    Chen, Yaoqing
    Gai, Weiwei
    Shi, Wei
    Li, Qiaoli
    Tien, Po
    Yan, Huimin
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 392 (04) : 582 - 587
  • [6] Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella Typhimurium
    Bargieri, Daniel Y.
    Leite, Juliana A.
    Lopes, Stefanie C. P.
    Sbrogio-Almeida, Maria Elisabete
    Braga, Catarina J. M.
    Ferreira, Luis C. S.
    Soares, Irene S.
    Costa, Fabio T. M.
    Rodrigues, Mauricio M.
    [J]. VACCINE, 2010, 28 (16) : 2818 - 2826
  • [7] Immunization of young African green monkeys with OprF epitope 8–OprI–type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa[J] . Eric T. Weimer,Sean E. Ervin,Daniel J. Wozniak,Steven B. Mizel.Vaccine . 2009 (48)
  • [8] Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin[J] . Langzhou Song,Yi Zhang,Nadezhda E. Yun,Allison L. Poussard,Jeanon N. Smith,Jennifer K. Smith,Viktoriya Borisevich,Jenna J. Linde,Michele A. Zacks,Hong Li,Uma Kavita,Lucia Reiserova,Xiangyu Liu,Kunmi Dumuren,Bhuvaneswari Balasubramanian,Bruce Weaver,Jason Parent,Scott Umlauf,Ge Liu,Jim Huleatt,Lynda Tussey,Slobodan Paessler.Vaccine . 2009 (42)
  • [9] Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin[J] . James W. Huleatt,Valerian Nakaar,Priyanka Desai,Yan Huang,Duane Hewitt,Andrea Jacobs,Jie Tang,William McDonald,Langzhou Song,Robert K. Evans,Scott Umlauf,Lynda Tussey,T.J. Powell.Vaccine . 2007 (2)
  • [10] IgA is important for clearance and critical for protection from rotavirus infection .2 S. E. Blutt,A. D. Miller,S. L. Salmon. MUCOSAL IMMUNOLOGY . 2012