首发精神分裂症外周血氧化应激状态改变

被引：17

作者：

晁阳阳 ^{[1
]}

盛卫勇 ^{[2
]}

赵瑾 ^{[1
]}

石玉中 ^{[3
]}

机构：

[1] 新乡医学院

[2] 郑州大学第一附属医院

[3] 河南省精神病医院(新乡医学院第二附属医院)

来源：

中国神经精神疾病杂志 | 2016年 / 42卷 / 08期

关键词：

首发精神分裂症; 氧化应激; 抗精神病药;

D O I：

暂无

中图分类号：

R749.3 [精神分裂症];

学科分类号：

100204 [神经病学];

摘要：

目的探讨首发精神分裂症患者外周血氧化应激变化及抗精神病药治疗对其影响。方法纳入47例首发未用药精神分裂症患者和43名正常对照,测定其外周血总超氧化物歧化酶(total superoxide dismutase,T-SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、过氧化氢酶(catalase,CAT)及总抗氧化能力(total antioxidant capacity of the body,T-AOC)活性。患者中18例完成单一利培酮6周治疗(利培酮组),25例完成单一奥氮平6周治疗(奥氮平组),治疗后再次测定外周血T-SOD、GSH-Px、CAT及T-AOC。结果与对照组相比,患者组治疗前T-SOD、GSH-Px降低(P<0.05),CAT升高(P<0.05),T-AOC差异无统计学意义(P>0.05)。利培酮组T-SOD活性在治疗后升高(P<0.05),奥氮平组T-AOC在治疗后升高(P<0.05),两组各氧化应激指标的变化值组间差异均无统计学意义(P>0.05)。结论首发精神分裂症患者抗氧化酶活性改变,这可能与精神分裂症病理机制有关。非典型抗精神病药利培酮和奥氮平可改善首发精神分裂症患者的氧化应激状态。

引用

页码：449 / 453

页数：5

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