强化降脂治疗对急性脑梗死患者血清炎症因子hs-CRP、IL-8、IL-6及MMP-9水平的影响

被引：25

作者：

李强

机构：

[1] 武汉市第五医院神经内科

来源：

中风与神经疾病杂志 | 2011年 / 28卷 / 05期

关键词：

脑梗死; 阿托伐他汀; 白细胞介素; 基质金属蛋白酶-9;

D O I：

10.19845/j.cnki.zfysjjbzz.2011.05.017

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨短期内使用阿托伐他汀强化降脂对急性脑梗死患者血清高敏C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)及基质金属蛋白酶-9(MMP-9)的影响,以了解其对脑梗死炎症抑制和颈动脉斑块稳定作用。方法 120例急性脑梗死患者患者根据颈动脉超声检查结果分为颈动脉稳定斑块组(n=60)和颈动脉易损斑块组(n=60)。抽血检查后随机分为常规治疗组60例(阿托伐他汀10mg/d,口服)和强化治疗组60例(阿托伐他汀40mg/d,口服)。所有患者药物治疗前和治疗后2w检测血脂及血清hs-CRP、IL-8、IL-6和MMP-9水平。结果治疗前常规治疗组和强化治疗组中血脂及血清hs-CRP、IL-8、IL-6和MMP-9水平差异无显著性(均P>0.05)。治疗后2w,强化治疗组中LDL-C、血清hs-CRP水平明显低于常规治疗组,差异具有著性(P<0.01),强化治疗组中两亚组(尤其是易损斑块组)血清IL-8、IL-6和MMP-9水平明显低于常规治疗组,差异具有显著性(P<0.01)。结论阿托伐他汀强化降脂能迅速降低脑梗死患者的血清炎症因子水平,具有抑制炎症和稳定斑块的作用。

引用

页码：445 / 448

页数：4

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