JNK信号通路与细胞凋亡关系的研究进展

被引：41

作者：

魏娜 ^{[1
]}

贺海波 ^{[2
]}

张长城 ^{[1
]}

袁丁 ^{[1
]}

王婷 ^{[1
]}

机构：

[1] 三峡大学医学院

[2] 天然产物研究与利用湖北省重点实验室(三峡大学)

来源：

中国临床药理学与治疗学 | 2013年 / 18卷 / 07期

关键词：

JNK信号通路; 细胞凋亡; 丝裂原活化蛋白激酶;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

c-Jun氨基末端激酶(c-Jun N-terminal ki-nase,JNK)信号通路是近20年来发现的与细胞分化、细胞凋亡、应激反应以及多种人类疾病的发生和发展关系非常密切的通路之一,其生物化学功能和对细胞生理、病理情况下的调节作用一直被国内外学者所关注。近年来,研究发现JNK信号通路在调控细胞凋亡中发挥重要作用,通过调节JNK信号通路有望成为治疗细胞凋亡引起的疾病的重要靶点。本文就其生物学功能及其与细胞凋亡关系作一阐述。

引用

页码：807 / 812

页数：6

共 19 条

[1]

JNK信号通路介导的凋亡在疾病中的作用[J]. 侯炳旭,冯丽英.世界华人消化杂志. 2011(17)

[2] 三氧化二砷通过JNK信号通路诱导K562细胞凋亡 [J].

章圣辉 ;

韩义香 ;

吴建波 ;

叶爱芳 ;

尹丽慧 ;

谭映霞 .

中国临床药理学与治疗学, 2008, (10) :1099-1103

[3] Ferulic acid attenuates ischemia/reperfusion-induced hepatocyte apoptosis via inhibition of JNK activation [J].

Kim, Hyo-Yeon ;

Lee, Sun-Mee .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 45 (05) :708-715

[4] Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-D-glucose-induced apoptosis in chronic myeloid leukemia K562 cells [J].

Kwon, Tae-Rin ;

Jeong, Soo-Jin ;

Lee, Hyo -Jeong ;

Lee, Hyo-Jung ;

Sohn, Eun Jung ;

Jung, Ji Hoon ;

Kim, Ji-Hyun ;

Jung, Deok-Beom ;

Lu, Junxaun ;

Kim, Sung-Hoon .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 424 (03) :530-537

[5] JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death [J].

Fernandes, Kimberly A. ;

Harder, Jeffrey M. ;

Fornarola, Laura B. ;

Freeman, Robert S. ;

Clark, Abbot F. ;

Pang, Iok-Hou ;

John, Simon W. M. ;

Libby, Richard T. .

NEUROBIOLOGY OF DISEASE, 2012, 46 (02) :393-401

[6] The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis [J].

Ghosh, Jyotirmoy ;

Das, Joydeep ;

Manna, Prasenjit ;

Sil, Parames C. .

BIOMATERIALS, 2011, 32 (21) :4857-4866

[7] Targeting the JNK Signaling Pathway Potentiates the Antiproliferative Efficacy of Rapamycin in LS174T Colon Cancer Cells [J].

Benoit, Michael ;

Dormond-Meuwly, Anne ;

Demartines, Nicolas ;

Dormond, Olivier .

JOURNAL OF SURGICAL RESEARCH, 2011, 167 (02) :E193-E198

[8]

Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK[J] . Joydeep Das,Jyotirmoy Ghosh,Prasenjit Manna,Parames C. Sil.Biochemical Pharmacology . 2011 (7)

[9] c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK [J].