具有抗肿瘤活性的姜黄素衍生物研究进展

被引：13

作者：

张欢 ^{[1
]}

房雷 ^{[2
]}

苟少华 ^{[2
]}

陈莉 ^{[1
]}

机构：

[1] 中国药科大学天然药物化学教研室

[2] 东南大学药物化学研究中心

来源：

药学进展 | 2014年 / 38卷 / 01期

关键词：

姜黄素; 结构修饰; 构效关系; 生物利用度;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

姜黄素是一种具有抗肿瘤、抗阿尔茨海默病、抗氧化、抗炎、抗病毒等多种生物活性的天然多酚,但其存在生物利用度低、水溶性较差等缺点,使其临床应用受到限制。基于此,研究人员对姜黄素展开了大量的结构改造工作,以期能改善其生物活性及成药性。综述了具有抗肿瘤活性的姜黄素衍生物的研究进展,旨在为相关药物的研发提供参考。

引用

页码：36 / 45

页数：10

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