局灶性脑缺血及再灌注损伤IGF-Ⅰ表达的动态变化

被引：6

作者：

徐忠信

何金婷

莽靖

胥桂华

杨宏

钱佳利

机构：

[1] 吉林大学中日联谊医院神经内科

[2] 长春中医学院生理学教研室吉林长春

[3] 吉林长春

来源：

吉林大学学报(医学版) | 2005年 / 03期

关键词：

脑缺血; 再灌注损伤; 胰岛素样生长因子-Ⅰ; 半影区;

D O I：

10.13481/j.1671-587x.2005.03.035

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

目的:探讨胰岛素样生长因子- (IGF- )在局灶性脑缺血再灌注损伤中的表达及作用。方法:采用线栓法制备大鼠局灶性脑缺血模型,应用免疫组化染色、原位杂交技术检测IGF- 蛋白及m RNA表达。结果:正常组织有极低水平的IGF- 表达,脑缺血后表达主要位于半影区,随缺血及缺血再灌注时间延长,半影区表达逐渐增强,IGF- 蛋白及m RNA表达在再灌注2 4 h为16 9.6 4±6 .97、16 8.6 4±6 .2 8,4 8h为16 8.86±5 .39、170 .86±5 .0 7,并达高峰。结论:内源性IGF- 表达增强,对局灶性脑缺血再灌注损伤具有保护作用。

引用

页码：401 / 403

页数：3

共 6 条

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