雌激素受体β基因CA重复序列多态性与绝经后骨质疏松症的关联性研究(英文)

被引：9

作者：

耿力 ^{[1
]}

姚珍薇 ^{[1
]}

杨洪昌 ^{[2
]}

骆建云 ^{[1
]}

韩力力 ^{[1
]}

卢起 ^{[1
]}

机构：

[1] 重庆医科大学附属第一医院妇产科

[2] 云南省创伤救治中心

来源：

遗传学报 | 2007年 / 10期

关键词：

骨质疏松症; 绝经后; 雌激素受体β(ESR2); 多态性; 骨密度;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

绝经后骨质疏松症(PMO)是一种多基因调控的遗传性疾病。雌激素受体β亚型基因是骨质疏松症的重要侯选基因。此文采用病例对照设计(78名股骨颈PMO病人和122名对照以及108名腰椎PMO病人和92名对照)研究中国人(汉族)雌激素受体β基因(ESR2)第5内含子CA重复序列多态性与PMO的相关性。以CA重复序列平均数22次为界将重复序列基因分为短基因(<22)和长基因(≥22),分别以S和L表示。股骨颈及腰椎(L2-4)部位,病例组中LL基因型和L等位基因者频率显著高于对照组(P<0.01),SL、LL及SL+LL基因型者较SS基因型者患PMO风险显著增高(P<0.05);调整年龄、绝经时间、绝经年龄及体质指数后,Logistic回归分析显示ESR2(CA)n多态性仍然与股骨颈(OR4.923,95%CI1.986～12.203,P=0.001)及L2-4(OR2.267,95%CI1.121～4.598,P=0.023)PMO显著相关。结果显示:ESR2基因CA重复序列多态性与股骨颈和L2-4部位PMO独立关联,L等位基因显性影响PMO的发病风险。

引用

页码：868 / 876

页数：9

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