越鞠甘麦大枣汤调节小鼠海马PKA-CREB-BDNF信号通路的抗抑郁作用（英文）

被引：27

作者：

张艺 ^{[1
]}

王江荟 ^{[1
]}

薛文达 ^{[1
]}

聂春莹 ^{[1
]}

盛莉 ^{[1
]}

陈刚 ^{[1
]}

王薇 ^{[1
,2
]}

机构：

[1] 南京中医药大学基础生物医学科学院转化系统生物学与神经科学中心中医脑病重点实验室

[2] 南京中医药大学心理学院

来源：

南京中医药大学学报 | 2018年 / 34卷 / 06期

关键词：

越鞠甘麦大枣汤; 抗抑郁样作用; PKA; CREB; BDNF;

D O I：

10.14148/j.issn.1672-0482.2018.0572

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的探讨越鞠甘麦大枣汤(YG)的抗抑郁功效及其与PKA-CREB-BDNF信号通路的关联。方法强迫游泳(FST)检测越鞠甘麦大枣汤单次给药后抗抑郁的时效性。慢性不可预测模型(CMS)进一步检测越鞠甘麦大枣汤在抑郁模型上的抗抑郁作用。蛋白印迹表达法检测越鞠甘麦大枣汤单次给药30min和24h后海马中PKA、CREB、BDNF的蛋白表达。结果YG在FST中显示出持久的抗抑郁潜力,并且快速逆转了慢性应激小鼠的抑郁样行为。在慢性小鼠模型中,海马中PKA,CREB和BDNF的表达显著上调。结论越鞠甘麦大枣汤(YG)显示出快速和持久的抗抑郁样作用,其抗抑郁功能与PKACREB-BNDF通路有关。

引用

页码：572 / 577

页数：6

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