白细胞介素-6阻断剂在类风湿关节炎的治疗应用

被引：18

作者：

姜楠

费允云

赵岩

机构：

[1] 中国医学科学院北京协和医学院北京协和医院内科

来源：

中华临床免疫和变态反应杂志 | 2012年 / 6卷 / 03期

关键词：

类风湿关节炎; 白细胞介素6; 托珠单抗;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

1002 ; 100201 ;

摘要：

类风湿关节炎(rheumatoid arthritis,RA)是一种系统性炎症性自身免疫性疾病。免疫系统的失调在其发病中起着重要作用,因而抑制炎症反应是治疗RA的重要手段。白细胞介素6(interleukin-6,IL-6)是多功能细胞因子,与RA的发病有着密切联系。阻断IL-6信号传导通路是RA治疗的一个新策略。托珠单抗(Tocilizumab)是人源化IL-6受体单克隆抗体,一系列随机双盲安慰剂对照临床试验已显示其对于RA患者的疗效和安全性。这一药物可能会为RA的治疗带来新的曙光。

引用

页码：232 / 236

页数：5

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