TNF-α诱导血管内皮细胞的衰老

被引：25

作者：

周建军

高云飞

王宏芳

陈佺

吴才宏

丰美福

机构：

[1] 北京大学生命科学学院生物膜与膜生物工程国家重点实验室

[2] 北京大学生命科学学院细胞生物学与遗传学系

[3] 中国科学院动物研究所生物膜与膜生物工程国家重点实验室

[4] 中

来源：

科学通报 | 2001年 / 19期

关键词：

TNF-α; 内皮细胞; 炎症反应; 衰老;

D O I：

暂无

中图分类号：

R339.38 [];

学科分类号：

071008 ;

摘要：

TNF-α是极为重要的促炎性细胞因子, 在调节细胞免疫反应中起着多种生理和病理作用. TNF- α能激活血管内皮细胞, 继而表达多种细胞因子和黏附分子引发一系列的炎性白细胞浸润和炎症反应. 研究发现TNF-α炎性刺激除了能引起内皮细胞死亡外, 还能诱导内皮细胞的衰老. TNF-α处理的血管内皮细胞衰老相关的β-半乳糖苷酶染色反应显示阳性, 细胞周期停滞在G0～G1期; 内皮细胞中线粒体膜电位早期上升, 衰老时则降低, 表征早期细胞线粒体功能亢进, 而后期功能衰退; 活性氧水平早期有上升和下降的振荡, 诱导衰老后有所降低. 结果表明线粒体的功能变化与TNF-α诱导的内皮细胞衰老有关.

引用

页码：1636 / 1640+1676 +1676

页数：6

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