家兔急性不完全性脑缺血模型和特点的实验研究

被引:2
作者
李盈盈 [1 ]
王子灿 [1 ]
李麟仙 [1 ]
机构
[1] 昆明医学院病理生理教研室
关键词
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
采用低压低灌流的方法造成家兔急性不完全性脑缺血。检测了皮层脑电图、心输出量、平均动脉压及脑静脉血LDH、CPK活性。于缺血60分时处死动物,测定大脑皮质水、钠、钾及环核苷酸含量,观察组织形态学改变。结果表明,通过低压低灌流成功地复制了兔急性不完全性脑缺血模型,其特点为脑电图严重抑制、大脑皮质水钠含量升高,钾和环核苷酸无明显改变,脑静脉血LDH及CPK活性显著升高,组织形态学改变提示发生了脑水肿。本文分析了上述改变发生的可能机理。
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