中晚期肾母细胞瘤术前介入治疗的临床研究

被引：9

作者：

李民驹

唐达星

周银宝

汤宏峰

机构：

[1] 浙江大学医学院附属儿童医院外科

[2] 浙江大学医学院附属儿童医院!杭州

[3] 放射科

[4] 病理科

来源：

中华小儿外科杂志 | 2001年 / 01期

关键词：

肾母细胞瘤; 肾动脉; 化学栓塞,治疗性;

D O I：

暂无

中图分类号：

R737.11 [肾、肾盂肿瘤];

学科分类号：

摘要：

目的　探讨介入性肾动脉栓塞化疗 (transcatheterarterialchemo embolization ,TACE)作为一种术前化疗方法治疗巨大或晚期肾母细胞瘤的可行性。方法　 10例巨大或晚期肾母细胞瘤术前行TACE ,栓塞剂为 40 %碘油 (或超液化碘油 ) 0 .5～ 0 .6ml/kg、阿霉素 10～ 15mg/m2 (体表面积 )和明胶海绵 ,2周后手术切除瘤肾。结果　TACE后有发热 ,但无骨髓抑制、肝肾功能和心电图改变 ,肿瘤缩小 ,手术时出血较少 ,易完整切除。治疗后有“降期”现象 ,有 5例因肿瘤彻底坏死而术后不能确定组织类型。结论　TACE的优点是化疗药物剂量小 ,全身副作用少 ,肿瘤坏死较彻底 ,可将术前治疗时间缩短为 2周 ,可作为一种术前化疗方法 ,单独应用或与全身用药并用于中晚期肾母细胞瘤的治疗。缺点与静脉用药术前化疗相似 ,有“降期”现象 ,且因肿瘤彻底坏死而组织分型困难。超声引导下经皮穿刺活检有助于在TACE前确定肿瘤组织类型

引用

页码：10 / 13

页数：4

共 9 条

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