Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury:mechanisms of brain tissue repair

被引：19

作者：

Zhen-qiang Zhang ^{[1
]}

Jun-ying Song ^{[1
]}

Ya-quan Jia ^{[1
]}

Yun-ke Zhang ^{[2
]}

机构：

[1] Henan University of Traditional Chinese Medicine

[2] First Affiliated Hospital of Henan University of Traditional Chinese Medicine

来源：

NeuralRegenerationResearch | 2016年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; Buyanghuanwu decoction; cerebral ischemia/reperfusion injury; ischemic cerebrovascular disease; integrin; αvβ3; vascular endothelial growth factor; angiogenesis; CD34; neural regeneration;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

Buyanghuanwu decoction has been shown to protect against cerebral ischemia/reperfusion injury,but the underlying mechanisms remain unclear.In this study,rats were intragastrically given Buyanghuanwu decoction,15 m L/kg,for 3 days.A rat model of cerebral ischemia/reperfusion injury was established by middle cerebral artery occlusion.In rats administered Buyanghuanwu decoction,infarct volume was reduced,serum vascular endothelial growth factor and integrin αvβ3 levels were increased,and brain tissue vascular endothelial growth factor and CD34 expression levels were increased compared with untreated animals.These effects of Buyanghuanwu decoction were partially suppressed by an angiogenesis inhibitor(administered through the lateral ventricle for 7 consecutive days).These data suggest that Buyanghuanwu decoction promotes angiogenesis,improves cerebral circulation,and enhances brain tissue repair after cerebral ischemia/reperfusion injury.

引用

页码：435 / 440

页数：6

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