窒息后新生儿心肌线粒体的损伤

被引：20

作者：

杨慧明

机构：

[1] 四川大学华西第二医院儿科

来源：

国外医学妇幼保健分册. | 2002年 / 02期

关键词：

心肌; 线粒体; 氧自由基; 钙超载; 呼吸链;

D O I：

暂无

中图分类号：

R722.1 [新生儿疾病];

学科分类号：

摘要：

新生儿窒息缺氧对心肌线粒体的损伤在心脏损害的过程中起着重要的作用。心肌线粒体是产生内源性自由基的主要场所 ,氧自由基攻击导致膜流动性下降 ,影响线粒体功能和膜内酶活性。心肌细胞缺血缺氧时细胞内钙超载继发线粒体钙超载 ,使线粒体内膜钙离子依赖小孔开放 ,线粒体膜电位降低和氧化磷酸化脱偶联。缺氧缺血时心肌线粒体内一氧化氮活酶 (NOS)类似物活性增强 ,NO产生增多 ,抑制线粒体呼吸链复合物活性和正常电子流 ,增加超氧阴离子的形成 ,导致心肌线粒体呼吸链功能受损 ,最终使ATP合成受阻 ,心肌能量供应不足 ,出现窒息新生儿心脏损害的临床表现。

引用

页码：89 / 91

页数：3

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