抗血小板药物作用机制及相关问题

被引:26
作者
李娟 [1 ,2 ]
李春坚 [1 ]
机构
[1] 南京医科大学第一附属医院(江苏省人民医院)心脏科
[2] 不详
关键词
抗血小板药物; 作用机制; 个体化治疗;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
抗血小板治疗是冠心病、缺血性脑卒中等血栓栓塞性疾病最重要的治疗措施之一。近十余年,随着抗栓领域基础研发及临床研究的逐步深入,出现了诸多新的抗血小板药物。文章综述了各种抗血小板药物的作用机制及临床应用中的相关问题,为实施规范化、个体化抗血小板治疗提供参考。
引用
收藏
页码:8 / 13
页数:6
相关论文
共 8 条
[1]  
Response Variability to P2Y 12 Receptor Inhibitors[J] . Jolanta M. Siller-Matula,Dietmar Trenk,Karsten Schr?r,Meinrad Gawaz,Steen D. Kristensen,Robert F. Storey,Kurt Huber.JACC: Cardiovascular Interventions . 2013 (11)
[2]  
Pharmacokinetics, Pharmacodynamics, and Safety of Ticagrelor in Volunteers With Severe Renal Impairment[J] . Kathleen Butler,Renli Teng.Journal of Clinical Pharmacology . 2012 (9)
[3]  
A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers[J] . Andrew L. Frelinger,Ronald D. Lee,Darcy J. Mulford,Jingtao Wu,Sai Nudurupati,Anu Nigam,Julie K. Brooks,Deepak L. Bhatt,Alan D. Michelson.Journal of the American College of Cardiology . 2012 (14)
[4]  
A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention[J] . Robert C. Welsh,Sunil V. Rao,Uwe Zeymer,Vivian P. Thompson,Kurt Huber,Janusz Kochman,Matthew W. McClure,Daniel D. Gretler,Deepak L. Bhatt,C. Michael Gibson,Dominick J. Angiolillo,Paul A. Gurbel,Lisa G. Berdan,Gayle Paynter,Sergio Leonardi,Mina Madan,Willia
[5]  
Efficacy and Safety of Glycoprotein IIb/IIIa Inhibitors During Elective Coronary Revascularization[J] . David E. Winchester,Xuerong Wen,William D. Brearley,Ki E. Park,R. David Anderson,Anthony A. Bavry.Journal of the American College of Cardiology . 2011 (10)
[6]  
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial[J] . Shamir R Mehta,Jean-Francois Tanguay,John W Eikelboom,Sanjit S Jolly,Campbell D Joyner,Christopher B Granger,David P Faxon,Hans-Jurgen Rupprecht,Andrzej Budaj,Alvaro Avezum,Petr Widimsky,Philippe Gabriel Steg,Jean-Pierre Bassand,Gilles Montalescot,Carlos Macaya,Giuseppe Di
[7]   Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate [J].
Bonello, Laurent ;
Tantry, Udaya S. ;
Marcucci, Rossella ;
Blindt, Ruediger ;
Angiolillo, Dominick J. ;
Becker, Richard ;
Bhatt, Deepak L. ;
Cattaneo, Marco ;
Collet, Jean Philippe ;
Cuisset, Thomas ;
Gachet, Christian ;
Montalescot, Gilles ;
Jennings, Lisa K. ;
Kereiakes, Dean ;
Sibbing, Dirk ;
Trenk, Dietmar ;
Van Werkum, Jochem W. ;
Paganelli, Franck ;
Price, Matthew J. ;
Waksman, Ron ;
Gurbel, Paul A. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (12) :919-933
[8]   Pharmacology of emerging novel platelet inhibitors [J].
Angiolillo, Dominick J. ;
Capranzano, Piera .
AMERICAN HEART JOURNAL, 2008, 156 (02) :S10-S15