子宫内膜癌p16/MTS1基因失活的研究

被引:1
作者
于莎莎
迟闺珠
朱章菱
肖白
王跃
机构
[1] 首都医科大学附属红十字朝阳医院妇产科
关键词
子宫内膜癌; p16/MTS1; 抑癌基因;
D O I
暂无
中图分类号
R737.33 [子宫肿瘤];
学科分类号
100214 ;
摘要
目的:探讨p16/MTS1基因在子官内膜癌组织的表达及意义.方法:采用显微切割-聚合酶链反应方法,对29例子宫内膜癌组织和癌旁正常组织中p16/MTS1基因纯合缺失进行检测.并用Fisher精确检验的方法,对p16/MTS1基因纯合缺失与临床病理关系进行统计分析.结果:29例子宫内膜癌组织,p16/MTS1基因纯合缺失率为24.14%.Ⅰ期纯合缺失率为24.00%,Ⅱ期纯合缺失率为33.33%.结论:p16/MTS1基因纯合缺失与子宫内膜癌的发生有关.
引用
收藏
页码:10 / 12
页数:3
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