双相情感障碍与DRD3、DRD2和COMT基因多态性的关联分析

被引：2

作者：

马小红

周琴

李涛

王英成

黄颐

孙学礼

刘协和

师建国

吴斌

机构：

[1] 四川大学华西医院心理卫生研究所

[2] 复旦大学公共卫生学院卫生统计与社会医学教研室

[3] 西安市精神卫生中心

[4] 西安市精神卫生中心成都

[5] 成都Department of Psychological Medicine

[6] Institute of Psychiatry

[7] Kings College

[8] UK

[9] 成都

来源：

中国神经精神疾病杂志 | 2003年 / 02期

关键词：

双相情感障碍; 多巴胺D3受体; 多巴胺D2受体; 儿茶酚氧位甲基转移酶;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的　探索多巴胺D3受体 (DRD3)、多巴胺D2受体 (DRD2 )和儿茶酚氧位甲基转移酶 (COMT)基因多态性与双相情感障碍的关系。方法　使用病例对照的关联分析方法 ,对 10 5名双相情感障碍患者和 12 8名对照者之DRD3、DRD2和COMT的多态性进行检测 ,并进行关联分析。结果　DRD3等位基因在两组间的分布有显著性差异 (χ2 =5 77,P =0 0 2 ) ,Logistic多元回归分析发现基因型 1/ 1和 2 / 2在两组间分布的有显著性差异 (P =0 0 36 ,OR=5 72 7) ,等位基因分析也有显著性差异 (P =0 0 2 2 ,OR =6 786 ) ;DRD2和COMT基因型和等位基因的分布在两组间无显著性差异 (χ2 =1 983,P =0 37/ χ2 =1 6 7,P =0 4 1;χ2 =0 2 16 ,P >0 0 5 / χ2 =0 14 3,P >0 0 5 ) ;将DRD3和DRD2共同分析时发现OR值升高 (OR =6 6 97)。结论　DRD3基因多态性与双相情感障碍有关联 ,且与DRD2有协同作用。

引用

页码：84 / 87

页数：4

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