硫氧还蛋白:一个肿瘤治疗的新靶点

被引：3

作者：

唐文心

王伟

陈正望

陈孝平

机构：

[1] 武汉市华中科技大学生命科学与技术学院生物物理所

来源：

现代生物医学进展 | 2009年 / 9卷 / 13期

关键词：

硫氧还蛋白; 肿瘤; 靶点;

D O I：

10.13241/j.cnki.pmb.2009.13.005

中图分类号：

Q51 [蛋白质];

学科分类号：

071010 ; 081704 ;

摘要：

硫氧还蛋白1(Thioredoxin-1,Trx-1)在多种肿瘤细胞和组织中均有过量的表达,它可以调节肿瘤细胞中凋亡通路、转录因子和某些功能蛋白酶的活性,进而影响着肿瘤的发生、发展、增殖、凋亡及血管发生等生理过程。而且,过量表达的Trx-1导致肿瘤细胞对多种治疗药物产生耐药性。近年来Trx-1已成为肿瘤研究的热点,是一个极有价值的肿瘤治疗的新靶点。

引用

页码：2558 / 2561

页数：4

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