喹硫平(思瑞康)单药或联合锂盐治疗双相躁狂发作的疗效和安全性

被引：9

作者：

刘林林

陈清刚

李刚

焦清艳

王莹

机构：

[1] 天津安定医院A病区

来源：

精神医学杂志 | 2010年 / 23卷 / 03期

关键词：

双相障碍; 喹硫平; 碳酸锂;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的比较喹硫平单药或联合锂盐治疗双相躁狂患者的疗效和安全性。方法 24例患者随机给予喹硫平单药或联合锂盐治疗,于基线、治疗第1、2、3、4周末,分别采用临床总体印象量表一双相障碍版(CGI-BP)、Young躁狂量表(YMRS)、阳性和阴性症状量表(PANSS)评定疗效。基线和终点时进行生化、血常规、尿常规以及心电图检查,以评价安全性。结果试验组和对照组的YMRS和PANSS的得分随着治疗时间而逐渐下降,每组各时间点之间存在统计学显著性(P<0.01),但是两组之间比较无统计学意义(P>0.05)。两组在有效率、痊愈率和病情改善方面比较无统计学意义(P>0.05),两组均未出现严重的不良事件。结论喹硫平(思瑞康)单药治疗双相障碍躁狂急性发作的疗效同联合碳酸锂治疗相当,但安全性高。

引用

页码：212 / 214

页数：3

共 10 条

[1]

Quetiapine monotherapy for mania associated with bipolar disorder:combined analysis of two international,double-blind,randomised,placebo-con-trolled studies. Vieta E,Mullen J,Brecher M,et al. Current Medical Research and Opinion . 2005

[2]

Quetiapine with lithium or divalproex for the treatment of bipolar mania:a ran-domized,double-blind,placebo-controled study. Sachs G,Chengappa KNP,Suppes T,et a1. Bipo-lar Disord . 2004

[3]

Placebo-level incidence of ex-trapyramidal symptoms(EPS)with quetiapine in controlled studies of patients with bipolar mania. Nasrallah HA,Brecher M,Paulsson B. Bipolar Disorders . 2006

[4]

Safety and tolera- bility of quetiapine in the treatment of acute mania in bipolar dis- order. ADLER CM,FLECK DE,BRECHER M,et al. Journal of Affective Disorders . 2007

[5]

Quetiapine for acute mania in bipolar disorder. Brahm NC,Gutierres SL,Carnahan RM. American Journal of Health System Pharmacy . 2007

[6]

The role of quetiapine in the treat-ment of bipolar disorder. Pini S,Abelli M,Cassano GB. Expert Opinion on Pharmacotherapy . 2006

[7]

Quetiapine alone and added to a mood stabilizer for serious mood disorders. Sajatovic M,Brescan DW,Perez DE,et al. Journal of Clinical Psychiatry . 2001

[8]

Treatment of agita- tion and aggression in bipolar mania:Efficacy of quetiapine. BUCKLEY PF,PAULSSON B,BRECHER M. Journal of Affective Disorders . 2007

[9]

A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder. CL Bowden,H Grunze,J Mullen. Journal of Clinical Psychiatry . 2005

[10]

Response and remission rates in Chi-nese patients with bipolar mania treated for4weeks with either quetiapine or lithium:a randomized and double-blind study. Li H,Ma C,Wang G. Current Medical Research and Opinion . 2008

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