分枝杆菌分泌系统

被引：1

作者：

李武 ^{[1
]}

王洪海 ^{[2
]}

谢建平 ^{[1
,2
]}

机构：

[1] 西南大学生命科学学院现代生物医药研究所

[2] 复旦大学生命科学学院遗传学研究所遗传工程国家重点实验室

来源：

中国生物化学与分子生物学报 | 2010年 / 26卷 / 08期

关键词：

分枝杆菌; 双精氨酸分泌系统; 通用型分泌系统; 替代型分泌系统; Ⅶ型分泌系统;

D O I：

10.13865/j.cnki.cjbmb.2010.08.002

中图分类号：

Q935 [微生物生理学];

学科分类号：

摘要：

分泌系统对于具有特殊细胞被膜结构的分枝杆菌,尤其是致病性分枝杆菌的存活和毒力非常重要.不少重要的致病因子或存活因子都通过特定的分泌系统进入环境,包括宿主体内.本文从分泌系统的基因、结构组成、分泌底物、转运机制及其与致病菌毒力的关系等几个方面介绍了分枝杆菌(mycobacteria)通用型分泌系统(general secretion pathway,SecA1)、替代型分泌系统(accessory Sec system,SecA2)、双精氨酸分泌系统(twin-arginine translocation,Tat)和Ⅶ型分泌系统(typeⅦsecretion systems,T7S system or ESX)4种分泌系统,并重点分析了Tat分泌系统.这些知识有利于从分泌系统及其底物的角度揭示结核分枝杆菌等胞内致病菌存活和逃避宿主免疫的机理,将为研发新的结核病控制措施提供依据.

引用

页码：697 / 704

页数：8

共 65 条

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