西地那非治疗肺动脉高压的研究

被引：14

作者：

吴文汇

荆志成

机构：

[1] 同济大学附属上海市肺科医院心肺循环中心

来源：

临床药物治疗杂志 | 2011年 / 9卷 / 01期

关键词：

西地那非; 肺动脉高压; 5型磷酸二酯酶抑制药;

D O I：

暂无

中图分类号：

R543.2 [肺动、静脉疾病];

学科分类号：

100201 [内科学];

摘要：

肺动脉高压是一种严重威胁人类身体健康的临床综合征,以肺血管阻力进行性升高为特征,最终发展至右心功能衰竭甚至死亡。5型磷酸二酯酶抑制药西地那非能选择性抑制5型磷酸二酯酶,可有效治疗肺动脉高压。目前已有大型临床研究证实西地那非可改善肺动脉高压患者症状,提高运动能力、生活质量和生存率;也有研究表明西地那非联合伊洛前列素或依前列醇治疗肺动脉高压优于单药治疗。西地那非安全性、耐受性好,最常见不良反应为头痛、腹泻、脸红、鼻衄等。目前有关西地那非治疗剂量、远期疗效及联合应用等仍需更多循证医学研究证实。

引用

收藏

页码：5 / 11

页数：7

相关论文

共 16 条

[1]

Addition of Inhaled Treprostinil to Oral Therapy for Pulmonary Arterial Hypertension.[J].Vallerie V. McLaughlin;Raymond L. Benza;Lewis J. Rubin;Richard N. Channick;Robert Voswinckel;Victor F. Tapson;Ivan M. Robbins;Horst Olschewski;Melvyn Rubenfire;Werner Seeger.Journal of the American College of Cardiology.2010, 18

[2]

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension [J].

Crosswhite, Patrick ;

Sun, Zhongjie .

JOURNAL OF HYPERTENSION, 2010, 28 (02) :201-212

[3]

Sildenafil for the Treatment of Pulmonary Hypertension in Pediatric Patients [J].

Huddleston, Alice J. ;

Knoderer, Chad A. ;

Morris, Jennifer L. ;

Ebenroth, Eric S. .

PEDIATRIC CARDIOLOGY, 2009, 30 (07) :871-882

[4]

Acute Hemodynamic Effects of Single-Dose Sildenafil When Added to Established Bosentan Therapy in Patients With Pulmonary Arterial Hypertension: Results of the COMPASS-1 Study [J].

Gruenig, Ekkehard ;

Michelakis, Evangelos ;

Vachiery, Jean-Luc ;

Vizza, Carmine Dario ;

Meyer, F. Joachim ;

Doelberg, Martin ;

Bach, Doris ;

Dingemanse, Jasper ;

Galie, Nazzareno .

JOURNAL OF CLINICAL PHARMACOLOGY, 2009, 49 (11) :1343-1352

[5]

Combined Use of PDE5 Inhibitors and Nitrates in the Treatment of Pulmonary Arterial Hypertension in Patients With Heart Failure [J].

Stehlik, Josef ;

Movsesian, Matthew A. .

JOURNAL OF CARDIAC FAILURE, 2009, 15 (01) :31-34

[6]

Successful Up-front Combination Therapy in a Patient With Idiopathic Pulmonary Hypertension and Patent Foramen Ovale: An Alternative to Epoprostenol Therapy? [J].

Pitsiou, Georgia G. ;

Chavouzis, Nikolaos ;

Nakou, Chrysanthi ;

Boutou, Afroditi K. ;

Argyropoulou, Paraskevi ;

Stanopoulos, Ioannis .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2009, 28 (06) :651-653

[7]

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association [J].

McLaughlin, Vallerie V. ;

Archer, Stephen L. ;

Badesch, David B. ;

Barst, Robyn J. ;

Farber, Harrison W. ;

Lindner, Jonathan R. ;

Mathier, Michael A. ;

McGoon, Michael D. ;

Park, Myung H. ;

Rosenson, Robert S. ;

Rubin, Lewis J. ;

Tapson, Victor F. ;

Varga, John ;

Harrington, Robert A. ;

Anderson, Jeffrey L. ;

Bates, Eric R. ;

Bridges, Charles R. ;

Eisenberg, Mark J. ;

Ferrari, Victor A. ;

Grines, Cindy L. ;

Hlatky, Mark A. ;

Jacobs, Alice K. ;

Kaul, Sanjay ;

Lichtenberg, Robert C. ;

Lindner, Jonathan R. ;

Moliterno, David J. ;

Mukherjee, Debabrata ;

Pohost, Gerald M. ;

Rosenson, Robert S. ;

Schofield, Richard S. ;

Shubrooks, Samuel J., Jr. ;

Stein, James H. ;

Tracy, Cynthia M. ;

Weitz, Howard H. ;

Wesley, Deborah J. .

CIRCULATION, 2009, 119 (16) :2250-2294

[8]

Addition of sildenafil in patients with pulmonary arterial hypertension with inadequate response to bosentan monotherapy [J].

Porhownik, Nancy R. ;

Al-Sharif, Hassan ;

Bshouty, Zoheir .

CANADIAN RESPIRATORY JOURNAL, 2008, 15 (08) :427-430

[9]

The anti proliferative effect of sildenafil on pulmonary artery smooth muscle cells is mediated via Upregulation of mitogen-activated protein kinase phosphatase-1 and degradation of extracellular signal-regulated kinase 1/2 phosphorylation [J].

Li, Bingbing ;

Yang, Lingchao ;

Shen, Jianying ;

Wang, Chunshen ;

Jiang, Zhen .

ANESTHESIA AND ANALGESIA, 2007, 105 (04) :1034-1041

[10]

Effects of escalating doses of sildenafil on hemodynamics and gas exchange in children with pulmonary hypertension and congenital cardiac defects [J].

Raja, Shahzad G. ;

Danton, Mark D. ;

MacArthur, Kenneth J. ;

Pollock, James C. .

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2007, 21 (02) :203-207