获得性肾小球疾病肾组织中nephrin的表达

被引：9

作者：

管娜

丁洁

张敬京

肖慧捷

刘景城

杨霁云

机构：

[1] 北京大学第一医院儿科,北京大学第一医院儿科,北京大学第一医院儿科,北京大学第一医院儿科,北京大学第一医院儿科,北京大学第一医院儿科,,,,,

来源：

中华儿科杂志 | 2001年 / 12期

关键词：

肾小球; 肾小球肾炎; 蛋白质类; 蛋白尿;

D O I：

暂无

中图分类号：

R692 [肾疾病];

学科分类号：

1002 ; 100210 ;

摘要：

目的　探讨nephrin在蛋白尿发生中的可能作用。方法　用免疫组化及图象分析的方法 ,分别对临床表现为大量蛋白尿 ,单纯性血尿患儿及对照组肾组织切片上nephrin的表达进行检测。结果　 (1)大量蛋白尿组的nephrin表达量为 0 6 2± 0 2 4,与单纯性血尿组 (0 6 7± 0 2 3)及对照组(0 82± 0 17)比较三者之间差异无显著意义 (P >0 0 5 )。 (2 )大量蛋白尿伴弥漫性足突融合组nephrin表达量为 0 6 1± 0 2 5 ,与大量蛋白尿不伴弥漫足突融合组 (0 6 2± 0 2 5 )及对照组比较三者间差异无显著意义 (P >0 0 5 )。 (3)弥漫足突融合微小病变组nephrin表达量为 0 5 0± 0 15 ,与非微小病变 (0 6 5±0 2 7)及对照组比较差异无显著意义 (P >0 0 5 )。结论　在获得性肾小球疾病中 ,用免疫组化的方法未能检测到肾小球nephrin的表达变化。

引用

页码：17 / 20

页数：4

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