原发性高血压患者血清vaspin水平与血压及UACR关系的研究

被引：11

作者：

高干

马琦琳

刘伟琦

机构：

[1] 中南大学湘雅医院心内科

来源：

临床心血管病杂志 | 2015年 / 31卷 / 03期

关键词：

内脏脂肪特异性丝氨酸蛋白酶抑制剂; 原发性高血压; 尿微量白蛋白/尿肌酐;

D O I：

10.13201/j.issn.1001-1439.2015.03.020

中图分类号：

R544.1 [高血压];

学科分类号：

摘要：

目的:观察原发性高血压患者血清内脏脂肪特异性丝氨酸蛋白酶抑制剂(visceral adipose tissue-derived serine protease inhibitor,vaspin)水平及尿微量白蛋白/尿肌酐(urine protein to creatine ratio,UACR),探讨血清vaspin与血压及UACR之间的关系。方法:选取就诊于湘雅医院并未行治疗的原发性高血压患者125例,其中原发性高血压UACR正常组67例(高血压组),原发性高血压UACR升高组58例(UACR组)。另选健康体检者53例为对照组。测定各组血清vaspin水平、尿微量白蛋白、尿肌酐值,计算比值。观察各组间血清vaspin水平、UACR值的差异,vaspin与血压及UACR的相关性。结果:高血压组血清vaspin水平低于对照组(P<0.05),UACR组血清vaspin水平低于高血压组(P<0.05)。相关分析显示vaspin水平与SBP、DBP、UACR呈负相关关系(r=-0.294,r=-0.589,r=-0.381;均P<0.01);UACR与SBP、DBP、LDL-C、Hs-CRP呈正相关关系(r=0.503,r=0.628,r=0.208,r=0.301;均P<0.01)。多元逐步回归显示vaspin为收缩压、舒张压、UACR的独立影响因素(偏相关系数β分别为-1.782,-1.874,-0.063;P值分别为0.000,0.000,0.030)。DBP为UACR的独立影响因素(偏相关系数β=0.065,P=0.000)。结论:原发性高血压患者血清vaspin水平与SBP、DBP、UACR显著负相关关系。vaspin水平可能是原发性高血压血压升高程度的一个评价指标及原发性高血压尿微量白蛋白的一个预测指标。

引用

页码：306 / 309

页数：4

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