脑啡肽与记忆巩固的调制Ⅰ.纳洛酮和甲啡肽对记忆巩固的影响和肾上腺去神经支配后的变化

被引：5

作者：

张世仪

McGaugh JL

机构：

[1] 中国医学科学院基础医学研究所生理研究室,ConterfortheNeurobiologyofLearningandMemory,UniversityofCaliforniaIrvine,USA北京

来源：

中国医学科学院学报 | 1987年 / 01期

关键词：

纳洛酮; 甲啡肽; 记忆保持; 抑制性回避反应; Y形迷宫辨别反应; 肾上腺去神经支配;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

实验结果表明在小鼠的两种行为实验中,训练后立即腹腔注射纳洛酮0.3 mg/kg能增强记忆的保持;注射甲啡肽0.5～2.0μg/kg则减弱记忆的保持。纳洛酮的效应可被同时注射吗啡或甲啡肽所阻断。切断支配小鼠肾上腺的神经后,同上剂量纳洛酮对记忆保持不再产生影响。此结果提示内源性甲啡肽和肾上腺髓质内分泌可能参与记忆巩固的调制。

引用

页码：60 / 64

页数：5

共 9 条

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