内源性一氧化碳对血管紧张素Ⅱ诱导的大鼠血管平滑肌细胞增殖的抑制作用

被引：9

作者：

胡昌兴

马业新

付度关

任澎

机构：

[1] 华中科技大学同济医学院附属同济医院心内科

来源：

中国心血管杂志 | 2003年 / 01期

关键词：

血红素氧合酶; 一氧化碳; 平滑肌细胞; 增殖;

D O I：

暂无

中图分类号：

R540.2 [];

学科分类号：

摘要：

目的　研究内源性一氧化碳 (CO)对血管紧张素 (Ang )诱导的大鼠血管平滑肌细胞 (VSMC)增殖的影响。方法　体外培养 Wistar大鼠主动脉 VSMC,用 Ang 诱导其增殖 ,分别用血红素氧合酶 1(HO- 1)的诱导剂和阻断剂 ,以诱导和阻断 HO- 1。通过酶联免疫法及同位素技术分别检测培养上清液中碳氧血红蛋白 (COHb)含量及VSMC3H-胸腺嘧啶核苷 (3H - Td R)掺入量。结果　氯血红素 (Hm )显著增高培养上清液中 COHb,对由 Ang 诱导的 VSMC3H - Td R掺入量的增高有显著抑制作用。结论　内源性 CO对 Ang 刺激的 VSMC的增殖有显著抑制作用。提示 HO- CO系统在血管成形术后再狭窄的发生和发展中有一定作用

引用

页码：4 / 5+8 +8

页数：3

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