以抑制小胶质细胞活化为靶标的抗神经退行性疾病的天然产物及衍生物的筛选与机制研究

被引：8

作者：

杨静玉 ^{[1
]}

陈国良 ^{[2
]}

吴春福 ^{[1
]}

机构：

[1] 沈阳药科大学药理教研室/辽宁省新药筛选重点实验室

[2] 沈阳药科大学药化教研室

来源：

世界科学技术(中医药现代化) | 2011年 / 01期

关键词：

神经退行性疾病; 小胶质细胞; MAPK/NF-κB; 信号通路; 人参皂苷; 姜黄素; 白藜芦醇;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

脑内小胶质细胞的活化贯穿了神经退行性疾病的发生、发展全过程。抑制小胶质细胞活化已经成为防治此类疾病的重要策略。本文对近年来本课题组在白藜芦醇及其衍生物、姜黄素及其衍生物、人参皂苷等抑制小胶质细胞活化方面的研究进展进行综述,为防治神经退行性疾病药物的深入研究提供参考。

引用

页码：18 / 24

页数：7

共 8 条

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[2]

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[3]

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[5]

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[6]

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[7]

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[8]

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