癌性神经病理性疼痛的阿片药物治疗

被引：35

作者：

李小梅 ^{[1
]}

董艳娟 ^{[1
]}

李慧莉 ^{[1
]}

王苏 ^{[1
]}

刘端祺 ^{[2
]}

机构：

[1] 北京军区总医院干三科

[2] 北京军区总医院专家组

来源：

中国疼痛医学杂志 | 2011年 / 17卷 / 08期

关键词：

阿片; 癌性神经病理性疼痛; 阿片受体亚型;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

癌性神经病理性疼痛常规镇痛治疗难以奏效,一直是癌痛临床治疗中临床医生和患者共同面对的一大困难与挑战。近年,阿片类药物逐渐成为一线治疗药物,针对神经病理性疼痛的形成机制和药物代谢、排泄及作用特点选择阿片类药物是目前临床研究的主流。在传统阿片药物中选择性应用具有双重作用机制的药物以及应用新型阿片药物可能成为改善神经病理性疼痛治疗效果的有效途径。

引用

页码：454 / 458

页数：5

共 8 条

[1]

Controlled-Release Oxycodone Alone or Combined with Gabapentin for Management of Malignant Neuropathic Pain.[J]..Chinese Journal of Cancer Research.2010, 01

[2]

Intravenous fentanyl patient-controlled analgesia for perioperative treatment of neuropathic/ischaemic pain in haemodialysis patients: a case series [J].

Karanikolas, M. ;

Aretha, D. ;

Kiekkas, P. ;

Monantera, G. ;

Tsolakis, I. ;

Filos, K. S. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2010, 35 (05) :603-608

[3]

The combination of morphine and minocycline may be a good treatment for intractable post-herpetic neuralgia [J].

Chen, Suchang ;

Hui, Hui ;

Zhang, Deren ;

Xue, Yanzhi .

MEDICAL HYPOTHESES, 2010, 75 (06) :663-665

[4]

Involvement of μ 1 -opioid receptor on oxycodone-induced antinociception in diabetic mice.[J].Chihiro Nozaki;Junzo Kamei.European Journal of Pharmacology.2007, 2

[5]

Transdermal fentanyl reduces pain and improves functional activity in neuropathic pain states [J].

Agarwal, Shefali ;

Polydefkis, Michael ;

Block, Brian ;

Haythornthwaite, Jennifer ;

Raja, Srinivasa N. .

PAIN MEDICINE, 2007, 8 (07) :554-562

[6]

Characterization of the antinociceptive effects of oxycodone in diabetic mice.[J].Chihiro Nozaki;Akiyoshi Saitoh;Junzo Kamei.European Journal of Pharmacology.2006, 1

[7]

Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain [J].

Erichsen, HK ;

Hao, JX ;

Xu, XJ ;

Blackburn-Munro, G .

PAIN, 2005, 116 (03) :347-358

[8]

Association of kappa opioid receptor mRNA upregulation in dorsal root ganglia with mechanical allodynia in mice following nerve injury [J].

Sung, B ;

Loh, HH ;

Wei, LN .

NEUROSCIENCE LETTERS, 2000, 291 (03) :163-166

← 1 →