去氢表雄酮抗促癌作用及其机理

被引：4

作者：

杨笋

付招娣

韩锐

机构：

[1] 中国医学科学院、中国协和医科大学药物研究所!北京,中国医学科学院、中国协和医科大学药物研究所!北京,中国医学科学院、中国协和医科大学药物研究所!北京

来源：

药学学报 | 2001年 / 08期

关键词：

去氢表雄酮; 肿瘤化学预防作用; 抗促癌作用;

D O I：

10.16438/j.0513-4870.2001.08.004

中图分类号：

R73-36 [治疗实验];

学科分类号：

100214 ;

摘要：

目的　探讨去氢表雄酮 (dehydroepiandrosterone,DHEA)抗促癌作用及机理。方法　用激光聚焦显微镜、流式细胞术、免疫荧光染色及小鼠耳部急性炎症等方法。结果　DHEA可明显抑制促癌剂巴豆油引起的小鼠急性耳肿胀 ;DHEA对巴豆油诱发的表皮细胞ODC活性升高也有显著的抑制作用。 10 - 7mol·L- 1 DHEA预处理可阻断佛波酯(TPA)刺激引起的S期细胞增加 ,并且对 [Ca2 + ]i和pH升高均有明显抑制作用。此外DHEA预处理可有效抑制蛋白激酶C α(PKC α)的活化。结论　DHEA有明显的抗促癌活性 ,可能与其对ODC活性和Ca2 + PKC DG信号传导通路的抑制有关

引用

页码：576 / 580

页数：5

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