应激导致抑郁症与单胺类递质系统稳态

被引：21

作者：

陈洁

黄宏平

机构：

[1] 皖南医学院细胞电生理研究室

来源：

生物学杂志 | 2013年 / 30卷 / 01期

关键词：

应激; 单胺类递质系统; 稳态; 抑郁症;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

当机体受到各种应激刺激时,机体会产生一系列特异性和非特异性反应,使机体的生理功能维持在新的稳态。如果应激持续时间过长,或者程度过于强烈,超过了机体稳态调节的范围,应激刺激就会对机体生理功能的稳态产生破坏。与应激相关的精神障碍不仅抑郁症一种,应激影响单胺类递质系统造成抑郁症可能主要是影响了5-HT递质系统的功能,而对NE递质系统或DA递质系统造成的影响不是导致抑郁症发病的主要原因。应激除了改变神经系统,还会影响机体内分泌系统,免疫系统,使抑郁症病人的发病和临床症状极为复杂。主要综述应激,特别是长期的、慢性的应激引起单胺能神经递质系统改变,进而导致抑郁症的神经生物学机制研究进展。

引用

页码：78 / 81

页数：4

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