紫草素抗炎的药理研究进展

被引：64

作者：

王钥 ^{[1
,2
]}

陈斌 ^{[3
]}

蔡蕊 ^{[1
,2
]}

卢悟广 ^{[1
,2
]}

徐留刚 ^{[1
,2
]}

曹鹏 ^{[1
,2
]}

周谦 ^{[1
,2
]}

沈建平 ^{[1
,2
]}

机构：

[1] 南京中医药大学附属中西医结合医院

[2] 江苏省中医药研究院

[3] 南京野生植物综合利用研究院

来源：

时珍国医国药 | 2020年 / 31卷 / 03期

关键词：

紫草素; 药理; 抗炎; 机制;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

紫草素(Shikonin)是传统中药紫草中提取的一种有效的萘醌类化合物,经过国内外数十年的研究,已被证实具有多种生物活性,包括抗炎、抗肿瘤、促进伤口愈合、抗菌、抗病毒、抗血栓、抗氧化、降血糖、保肝护肝等多种作用,尤其在过去几年,其抗炎的药理特性引发人们研究的兴趣。通过以"Shikonin"为关键词,在PubMed数据库中查询近5年的文献,共检索到相关文献290篇,其中抗炎的有效文献30余篇。文章总结了关于紫草素的最新抗炎研究成果,对紫草素抗炎的作用靶点进行总结归纳以供研究参考。

引用

页码：682 / 685

页数：4

共 16 条

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[2]

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[4]

Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis; inflammation; apoptosis and ER stress.[J].Jun Yang;Zhao Wang;Dong-Lin Chen.Biomedicine & Pharmacotherapy.2017,

[5]

Shikonin alleviates allergic airway remodeling by inhibiting the ERK-NF-κB signaling pathway.[J].Tian-Yue Wang;Qian-Lan Zhou;Miao Li;Yun-Xiao Shang.International Immunopharmacology.2017,

[6]

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[7]

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[8]

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[9]

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[10]

Shikonin inhibits inflammatory responses in rabbit chondrocytes and shows chondroprotection in osteoarthritic rabbit knee [J].

Li, Feng ;

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Yang, Wei ;

Chang, Ruimiao ;

Ma, Kaige ;

Qiu, Yusheng .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 29 (02) :656-662

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