多囊卵巢综合征表观遗传学发病机制的研究现状

被引：20

作者：

于玲玉 ^{[1
]}

孙振高 ^{[2
]}

机构：

[1] 山东中医药大学

[2] 山东中医药大学附属医院生殖与遗传中心

来源：

中国性科学 | 2019年 / 28卷 / 08期

关键词：

多囊卵巢综合征; 表观遗传学; 发病机制; 基因; DNA甲基化; 微小RNA;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病];

学科分类号：

100211 [妇产科学];

摘要：

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄妇女常见的内分泌失调和代谢紊乱性疾病,在女性生殖年龄非常普遍。PCOS的确切病理生理学机制仍不清楚。近年来,越来越多的证据表明,表观遗传学参与了PCOS的发病机制,其中包括DNA甲基化、组蛋白修饰、非编码RNA及微小RNA等内容。患有PCOS的女性有不同的表观遗传调控,不适当的表观遗传重组被认为是导致该疾病的常见原因。本文就近几年表观遗传学在PCOS发病机制中的作用的研究进展作一综述。

引用

页码：77 / 80

页数：4

共 10 条

[1]

Elevated levels of the circulatory ischemia-modified albumin in patients with polycystic ovary syndrome: a meta-analysis [J].

Reddy, Varikasuvu Seshadri ;

Bukke, Suman ;

Munikumar, Manne .

GYNECOLOGICAL ENDOCRINOLOGY, 2018, 34 (10) :868-874

[2]

MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study [J].

Yang, Ying ;

Jiang, Hua ;

Xiao, Ling ;

Yang, Xuezhou .

ONCOLOGY REPORTS, 2018, 39 (06) :3073-3085

[3]

Expression profiles of mRNA and long noncoding RNA in the ovaries of letrozole-induced polycystic ovary syndrome rat model through deep sequencing.[J].Lu-lu Fu;Ying Xu;Dan-dan Li;Xiao-wei Dai;Xin Xu;Jing-shun Zhang;Hao Ming;Xue-ying Zhang;Guo-qing Zhang;Ya-lan Ma;Lian-wen Zheng.Gene.2018,

[4]

Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population.[J].Weixi Xiong;Ying Lin;Lili Xu;Amin Tamadon;Shien Zou;Fubo Tian;Ruijin Shao;Xin Li;Yi Feng.Journal of Ovarian Research.2017, 1

[5]

Which origin for polycystic ovaries syndrome: Genetic, environmental or both? [J].

Fenichel, Patrick ;

Rougier, Charlotte ;

Hieronimus, Sylvie ;

Chevalier, Nicolas .

ANNALES D ENDOCRINOLOGIE, 2017, 78 (03) :176-185

[6]

Genome-wide association study for SNPs associated with PCOS in human patients [J].

Chen, Li ;

Hu, Ling-Min ;

Wang, Yu-Feng ;

Yang, Hai-Yan ;

Huang, Xiao-Yang ;

Zhou, Wei ;

Sun, Hai-Xiang .

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (05) :4896-4900

[7]

The role of aquaporins in polycystic ovary syndrome – a way towards a novel drug target in PCOS.[J].Agata Wawrzkiewicz-Jałowiecka;Karolina Kowalczyk;Dagmara Pluta;Łukasz Blukacz;Paweł Madej.Medical Hypotheses.2017,

[8]

Telomeric repeat-containing RNA (TERRA) related to polycystic ovary syndrome (PCOS) [J].