Th细胞分化调节机制研究进展

被引:8
作者
邢同京
章廉
骆抗先
机构
[1] 第一军医大学南方医院感染病科!广州
关键词
Th1/Th2细胞; 分化;
D O I
暂无
中图分类号
R392.12 [免疫细胞生物学];
学科分类号
100102 ;
摘要
Th细胞可分化为Th1和Th2细胞亚群 ,分别介导细胞和体液免疫反应。本文从分子水平阐明Th细胞分化的调节机制 ,藉以了解其对许多疾病的治疗及对免疫病理反应干预的重要意义。
引用
收藏
页码:127 / 128
页数:2
相关论文
共 11 条
[1]  
Preferential expression of CD30 by human CD4+T cells producing Th2-type cytokines. Del Prete G,Carli MD,Almerigogna F,et al. The FASEB Journal . 1995
[2]  
An interleukin-4 independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 recepter-deficient mice. Trauth N,Shulth LD,Brombacher F,et al. Proceedings of the National Academy of Sciences of the United States of America . 1997
[3]  
Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. Chow YH,Chiang BL,Lee YL,et al. J Immunol . 1998
[4]  
Defective T cell differentiation in the absence of Jnk1. Dong C,Yang DD,Wysk M,et al. Science . 1998
[5]  
Regulation of T helper cell differentiation by STAT molecules. Kaplan MH,Grusby MJ. Journal of Leukocyte Biology . 1998
[6]  
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways:Application to autoimmune disease therapy. Kuchroo VK,Das MP,Brown JA,et al. Cell . 1995
[7]  
Lack of Interferon-γreceptor βchain and the prevention of interferon-γsignaling in Th1 cells. Pernis A,Gupta S,Gollob KJ,et al. Science . 1995
[8]  
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. Pfeiffer C,Stein J,Southwood S,et al. The Journal of Experimental Medicine . 1995
[9]  
Regulation of the IL-12β2 subunit expression in developing Th1 and Th2 cells. Rogge L,Dighe AS,Gubler U,et al. The Journal of Experimental Medicine . 1997
[10]  
The antiviral compound ribavirin modulates the T helper(Th)1/Th2 subest balance in hepatitis B and C virus-specific immune responses. Hultgren C,Milich DR,Weiland O,et al. Journal of General Virology . 1998