丘脑:痛觉内源性调控作用的“启动子”

被引：37

作者：

雷静

尤浩军

机构：

[1] 西安交通大学医学部疼痛生物医学研究中心

来源：

中国疼痛医学杂志 | 2015年 / 21卷 / 06期

关键词：

丘脑; 丘脑“伤害性反应辨别器”; 痛觉内源性调控;

D O I：

暂无

中图分类号：

R338 [神经生理学];

学科分类号：

100115 [医学神经生物学];

摘要：

作为多种感觉信息传导的中继站,丘脑不仅接受自脊髓上行的伤害性信息传入,同时也将上述信息予以加工、整合并传递至大脑皮层的不同区域。目前,丘脑在痛觉感知和调控中的作用已愈发受到科研工作者的关注。最近,丘脑背内侧核和腹内侧核更被证实能对外周不同性质的伤害性传入信息给予高度的辨识,并可启动不同的内源性下行调控作用:易化和抑制。结合近年国内、外研究成果,本文将对生理性痛和病理性痛状态下丘脑对痛觉感知和调控的影响及相关机制给予简要综述。

引用

页码：401 / 403

页数：3

共 16 条

[1]

Effects of simulated weightlessness on intramuscular hypertonic saline induced muscle nociception and spinal Fos expression in rats.[J].Jing Lei;Antti Pertovaara;Hao-Jun You.Brain Research.2015,

[2]

Influence of intramuscular heat stimulation on modulation of nociception: complex role of central opioid receptors in descending facilitation and inhibition [J].

You, Hao-Jun ;

Lei, Jing ;

Ye, Gang ;

Fan, Xiao-Li ;

Li, Qiang .

JOURNAL OF PHYSIOLOGY-LONDON, 2014, 592 (19) :4365-4380

[3]

Roles of the periaqueductal gray in descending facilitatory and inhibitory controls of intramuscular hypertonic saline induced muscle nociception.[J].Jing Lei;Tao Sun;Bridget M. Lumb;Hao-Jun You.Experimental Neurology.2014,

[4]

Endogenous descending facilitation and inhibition differ in control of formalin intramuscularly induced persistent muscle nociception.[J].Jing Lei;Hao-Jun You.Experimental Neurology.2013,

[5]

Specific thalamic nuclei function as novel ‘nociceptive discriminators’ in endogenous control of nociception in rats.[J]..Neuroscience.2012,

[6]

Lei, Jing ;

Jin, Lin ;

Zhao, Ye ;

Sui, Mei-Yu ;

Huang, Li ;

Tan, Yong-Xiang ;

Chen, Yan-Ke ;

You, Hao-Jun .

EXPERIMENTAL NEUROLOGY, 2011, 228 (02) :206-214

[7]

Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception [J].

You, Hao-Jun ;

Lei, Jing ;

Sui, Mei-Yu ;

Huang, Li ;

Tan, Yong-Xiang ;

Tjolsen, Arne ;

Arendt-Nielsen, Lars .

JOURNAL OF PHYSIOLOGY-LONDON, 2010, 588 (21) :4177-4188

[8]

Functional connectivity of the secondary somatosensory cortex of the rat [J].

Liao, Chia-Chi ;

Yen, Chen-Tung .

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2008, 291 (08) :960-973

[9]

Plasticity of pain-related neuronal activity in the human thalamus.[J].W.S. Anderson;S. Ohara;H.C. Lawson;R.-D. Treede;F.A. Lenz.Progress in Brain Research.2006,

[10]

A comparative reappraisal of projections from the superficial laminae of the dorsal horn in the rat: The forebrain.[J]..J. Comp. Neurol..2003, 1

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