不同程度炎症的人牙龈树突状细胞的数量研究

被引:1
作者
刘宇
林松杉
章禾
刘奕
机构
[1] 海军总医院口腔科
关键词
郎格罕细胞; 牙龈炎; 牙周病;
D O I
暂无
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
目的:比较不同程度炎症的人牙龈树突状细胞的数量。方法:使用CD1a单克隆抗体和DC-SIGN单克隆抗体,分别对人牙龈郎格罕细胞(Langerhans cells,LCs)和真皮树突细胞(dermal dendritic cells,DDCs)作免疫组织化学染色,对正常(11例)、牙龈炎(14例)、牙周炎(15例)三组样本的两种细胞进行计数并比较。结果:LCs主要分布在牙龈上皮的基底层及棘层,高倍视野下三组样本的细胞数量分别是13±3.3、21±5.1、42±4.8(p<0.01);DDCs主要分布在牙龈上皮的基底膜以下,高倍视野下三组样本的细胞数量分别是27±6.3、33±5.1、76±4.8(p<0.01)。结论:牙龈的LCs和DDCs的数量与牙周炎症发展过程有关。
引用
收藏
页码:283 / 285
页数:3
相关论文
共 11 条
[1]  
Mature dendritic cellsinfiltrate the T cell-rich region of oral mucosa in chronicperiodontitis:in situ,in vivo,and in vitro studies. Jotwani R,Palucka AK,Al-Quotub M,et al. J Immunol . 2001
[2]  
Dendritic cells and the control ofimmunity. Banchereau J,Steinman RM. Nature . 1998
[3]  
Dendritic Cells at the Oral Mucosal Interface. Cutler CW,Jotwani R. Journal of Dental Research . 2006
[4]  
Factor XIIIa+dendriticcells and S-100protein+Langerhans’cells in adult periodontitis. Dereka XE,Tosios KI,Chrysomali E,et al. Journal of Periodontal Research . 2004
[5]  
Oral mucosal Langerhans cellsexpress DR and DQ antigens. Walsh LJ,Seymour GJ,Savage NW. Journal of Dental Research . 1986
[6]  
Antigen-presentation and the role of dendriticcells in periodontitis. Cutler CW,Jotwani R. Journal of Periodontology . 2000
[7]  
Antigen-presenting cells inhuman periodontal disease tissues. Gemmell E,Carter CL,Hart DN,et al. Oral Microbiology and Immunology . 2002
[8]  
Immunohistological and morphometricanalysis of intra-epithelial lymphocytes and Langerhans cells inhealthy and diseased human gingival tissues. Seguier S,Godeau G,Brousse N. Archives of Oral Biology . 2000
[9]  
Human gingival Langerhans cells in healthand disease. Newcomb GM,Powell RN. Journal of Periodontal Research . 1986
[10]  
Multiple dendritic cell(DC)subpop-ulations in human gingiva and association of mature DCs with CD4+T-cellsin situ. Jotwani R,Cutler CW. Journal of Dental Research . 2003