COPD频繁急性加重表型的识别及频繁急性加重原因研究进展

被引:9
作者
黄照明 [1 ,2 ]
刘翱 [2 ]
机构
[1] 昆明医科大学成都军区昆明总医院临床学院
[2] 成都军区昆明总医院呼吸内科
关键词
慢性阻塞性肺疾病; 频繁急性加重; 表型; 原因;
D O I
暂无
中图分类号
R563.9 [其他];
学科分类号
100201 [内科学];
摘要
<正>慢性阻塞性肺疾病(COPD)的特征是累及气道、肺实质及肺血管的慢性炎症,气流受限不完全可逆,呈进行性发展。COPD是一种异质性疾病,有学者用不同的表型对COPD异质性进行描述和研究,美国学者在共识报告中提出,"表型"是COPD未来的研究方向[1]。COPD患者对急性加重易感性不同,表现为急性加重频率的异质性。2013版GOLD对这类患者推荐的干预措施也与其他患者不同。
引用
收藏
页码:684 / 686
页数:3
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共 5 条
[1]
Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population [J].
Ishii, Takeo ;
Motegi, Takashi ;
Kamio, Koichiro ;
Gemma, Akihiko ;
Kida, Kozui .
RESPIROLOGY, 2014, 19 (04) :590-595
[2]
Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD [J].
Makela, Mika J. ;
Backer, Vibeke ;
Hedegaard, Morten ;
Larsson, Kjell .
RESPIRATORY MEDICINE, 2013, 107 (10) :1481-1490
[3]
Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD [J].
Cazzola, Mario ;
Capuano, Annalisa ;
Rogliani, Paola ;
Matera, M. Gabriella .
CURRENT OPINION IN PHARMACOLOGY, 2012, 12 (03) :300-308
[4]
Development of the EXAcerbations of Chronic Obstructive Pulmonary Disease Tool (EXACT): A Patient-Reported Outcome (PRO) Measure [J].
Leidy, Nancy Kline ;
Wilcox, Teresa K. ;
Jones, Paul W. ;
Murray, Lindsey ;
Winnette, Randall ;
Howard, Kellee ;
Petrillo, Jennifer ;
Powers, John ;
Sethi, Sanjay .
VALUE IN HEALTH, 2010, 13 (08) :965-975
[5]
Frequent Chronic Obstructive Pulmonary Disease Exacerbators: How Much Real, How Much Fictitious? [J].
Jose Soler-Cataluna, Juan ;
Rodriguez-Roisin, Roberto .
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2010, 7 (04) :276-284