胞质附着蛋白与血脑屏障

被引：2

作者：

谭晓琳 ^{[1
]}

吕超 ^{[1
]}

于一凡 ^{[1
]}

隗金成 ^{[2
]}

赵祯 ^{[3
]}

机构：

[1] 中国医科大学

[2] 中国医科大学七年制办公室

[3] 中国医科大学生理教研室

来源：

医学综述 | 2009年 / 15卷 / 21期

关键词：

血脑屏障; 胞质附着蛋白; 脑缺血;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

ZO蛋白家族是构成血脑屏障的重要蛋白,主要在上皮和内皮细胞的紧密连接处表达。作为一种胞质附着蛋白,它对紧密连接的稳定起重要作用。当ZO蛋白家族出现结构和功能上的障碍时,血脑屏障功能即随之改变。所以,研究ZO蛋白家族结构和功能的改变,为选择性开放血脑屏障提供了新的途径。本文对ZO蛋白家族的结构、功能以及对血脑屏障调节的影响进行综述。

引用

页码：3227 / 3229

页数：3

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