神经病理性疼痛中背根神经节交感神经芽生的机制研究

被引：24

作者：

徐江涛

马柯

机构：

[1] 上海交通大学医学院附属新华医院疼痛科

来源：

中国疼痛医学杂志 | 2015年 / 21卷 / 07期

关键词：

神经病理性疼痛; 背根神经节; 交感神经; 轴突; 芽生;

D O I：

暂无

中图分类号：

R402 [];

学科分类号：

摘要：

神经病理性疼痛是临床顽疾之一,发病机制复杂。研究表明外周神经病理性疼痛模型背根神经节(dorsal root ganglion,DRG)中存在交感神经轴突末梢的出芽增生,或与神经病理性疼痛发生机制密切相关。DRG交感轴突出芽增生可能与传入神经元异常自发放电、细胞因子释放、胶质细胞激活、神经营养因子释放以及交感神经轴突再生相关。临床应用神经阻滞疗法或许是治疗神经病理性疼痛的早期干预方法之一。

引用

页码：481 / 485

页数：5

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