左旋多巴诱导的帕金森病异动症与COMT活性变化的研究进展

被引：9

作者：

孔德南

王蓄

张丽梅

机构：

[1] 哈尔滨医科大学第二附属医院神经内科

来源：

卒中与神经疾病 | 2014年 / 21卷 / 02期

关键词：

左旋多巴; 抑制剂; 浮选药剂; 异动症; COMT; 帕金森病;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

摘要：

<正>左旋多巴诱导的帕金森病异动症发病机制尚未明确,受多种神经元、神经递质、受体和酶的调控,近年来通过大量文献阅读和研究发现,儿茶酚胺氧位甲基转移酶(COMT)活性变化与异动症的相关性越来越受到关注,本研究就左旋多巴诱导的帕金森病异动症与COMT活性变化相关性的研究进展进行综述,为左旋多巴诱发异动症的治疗研究提供新思路。帕金森病是常见的慢性进展性中枢神经系统变性疾病,帕金森病患者通常在左旋多巴治疗5～10年后有50%以上的患者会出现药效消失、运动波动等并发症[1],运动并发症

引用

页码：122 / 124

页数：3

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