肝X受体在胆固醇代谢过程中的作用机制

被引：22

作者：

陈裕

范晓飞

郑忠清

王邦茂

机构：

[1] 天津医科大学总医院消化科天津市消化病学研究所

来源：

临床肝胆病杂志 | 2016年 / 32卷 / 05期

关键词：

胆固醇; 肝X受体; 胆酸类; 综述;

D O I：

暂无

中图分类号：

R333 [消化与吸收生理];

学科分类号：

100123 [人体微生态学];

摘要：

胆固醇是细胞膜的组成成分,对维持机体代谢及正常的功能有着至关重要的作用。肝X受体(LXR)是肝脏中丰富表达的一种核受体,通过在肝细胞层面调控胆固醇及胆汁酸的合成、转化及转运来影响胆固醇代谢过程,在维持机体胆固醇稳态中发挥重要作用。另外,LXR能抑制食物中胆固醇在肠道的吸收,从而降低机体外源性胆固醇水平,从一定程度上降低机体总胆固醇水平,预防高胆固醇血症、胆结石等的形成。从肝脏和肠道两个层面对LXR调控胆固醇代谢的机制进行了总结。

引用

页码：1013 / 1017

页数：5

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